Nat：蝙蝠冠状病毒对人体细胞有传染可能 有效结合hACE2

顾汉现

与新冠病毒 相关的蝙蝠冠状病毒及其对人体细胞的传染性

领研网

2022/04/24

论文
论文标题：Bat coronaviruses related to SARS-CoV-2 and infectious for human cells
作者：Sarah Temmam, Khamsing Vongphayloth, Marc Eloit, et al.
期刊：Nature
发表时间：2022/02/16
数字识别码：10.1038/s41586-022-04532-4
摘要：The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related viruses in Asian Rhinolophus bats1,2,3,4, including the closest virus from R. affinis, RaTG13 (refs. 5,6), and pangolins7,8,9. SARS-CoV-2 has a mosaic genome, to which different progenitors contribute. The spike sequence determines the binding affinity and accessibility of its receptor-binding domain to the cellular angiotensin-converting enzyme 2 (ACE2) receptor and is responsible for host range10,11,12. SARS-CoV-2 progenitor bat viruses genetically close to SARS-CoV-2 and able to enter human cells through a human ACE2 (hACE2) pathway have not yet been identified, although they would be key in understanding the origin of the epidemic. Here we show that such viruses circulate in cave bats living in the limestone karstic terrain in northern Laos, in the Indochinese peninsula. We found that the receptor-binding domains of these viruses differ from that of SARS-CoV-2 by only one or two residues at the interface with ACE2, bind more efficiently to the hACE2 protein than that of the SARS-CoV-2 strain isolated in Wuhan from early human cases, and mediate hACE2-dependent entry and replication in human cells, which is inhibited by antibodies that neutralize SARS-CoV-2. None of these bat viruses contains a furin cleavage site in the spike protein. Our findings therefore indicate that bat-borne SARS-CoV-2-like viruses that are potentially infectious for humans circulate in Rhinolophus spp. in the Indochinese peninsula.

所属学科：
病毒学

（导读 阿金）本研究发现在洞穴蝙蝠中流行的冠状病毒的受体结合结构域与新冠病毒的差异仅限于ACE2结合界面上的一两个残基，与新冠病毒武汉分离株相比，可更有效地结合hACE2蛋白，同时介导人体细胞内的hACE2依赖性进入和复制。该发现结果表明蝙蝠传播的新冠病毒样病毒有潜力感染人类并传播。

文章标签
蝙蝠
冠状病毒
新冠病毒
ACE2结合界面

https://www.nature.com/articles/s41586-022-04532-4

https://www.linkresearcher.com/t ... 2-bd1b-c0f48ee13658

http://www.kaseisyoji.com/forum. ... &extra=page%3D3



华成旅行社  欢迎来电咨询：

电话：03-3833-9823  / 03-5688-1863
FAX ：03-3833-9873  / 03-3834-5891

SOFTBANK电话：080-3416-2275   担当：小郭  微信号：08034162275
SOFTBANK电话：090-2172-4325   担当：小于  微信号：TYOSCL4325
SOFTBANK电话：080-3398-4387   担当：小李  微信号：huacheng4387
SOFTBANK电话：080-3523-4388   担当：小何  微信号：huacheng602
SOFTBANK电话：080-3084-4389   担当：小马  微信号：huacheng858

http://www.kaseisyoji.com/forum.php?mod=forumdisplay&fid=10