不生癌（一生中从不生癌、终生不生癌，治癒后不复发等）

顾汉现

不生癌（一生中从不生癌、终生不生癌，并包括临床治癒后不复发） 主要参考文献：
(Translated by Baidu: )
Non cancer (never developing cancer in one's lifetime, never developing cancer in one's lifetime, and including non recurrence after clinical cure) Main references:
（百度翻訳： ）
不生癌（一生に不生癌、生涯不生癌、そして臨床治癒後に再発しないことを含む）主な参考文献：

（各种癌症的预防和治疗等、约10年前已经基本解决了。）

1.Nature：重磅！新型抗癌药物或能让癌细胞处于永久休眠状态！
http://news.bioon.com/article/6725571.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95262
组蛋白乙酰基转移酶KAT6A / B抑制剂诱导衰老并阻止肿瘤生长
Jonathan B. Baell, David J. Leaver, Stefan J. Hermans, et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature (2018), DOI: 10.1038/s41586-018-0387-5
https://www.nature.com/articles/s41586-018-0387-5

2.Science：重大突破！揭示γδ T细胞检测癌症和感染新机制
http://news.bioon.com/article/6749093.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
Sci:γδ T细胞检测癌症和感染 感应磷酸抗原 根除患病细胞
Marc Rigau et al. Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells. Science, 2020, doi:10.1126/science.aay5516.
https://science.sciencemag.org/c ... /08/science.aay5516

3.Nature：脑瘤恶化伴随神经网络的重塑
http://news.bioon.com/article/6749777.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
PIK3CA变体在神经胶质瘤形成过程中选择性启动脑活动亢进
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
https://www.nature.com/articles/s41586-020-1952-2

4.Nature：科学家鉴别出引发儿童肾脏癌症的新型机制
http://news.bioon.com/article/6748696.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
染色质读取器中的功能获得突变导致细胞命运受损
Wan, L., Chong, S., Xuan, F. et al. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature 577, 121–126 (2020) doi:10.1038/s41586-019-1842-7
https://www.nature.com/articles/s41586-019-1842-7

5.《科学》：儿童肾癌始于胚胎时期
http://paper.sciencenet.cn/htmlp ... 12501383454010.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
肾母细胞瘤的胚胎前体
Embryonal precursors of Wilms tumor
Tim H. H. Coorens1, Taryn D. Treger1,2,3, Reem Al-Saadi4,5, Luiza Moore1,2, Maxine G. B. Tran6,7, Thomas J. Mitchell1,2,8, Suzanne Tugnait4, Christine Thevanesan4, Matthew D. Young1, Thomas R. W. Oliver1,2,9, Minou Oostveen4,5, Grace Collord1,2,3, Patrick S. Tarpey2, Alex Cagan1, Yvette Hooks1, Mark Brougham10, Ben C. Reynolds11, Giuseppe Barone5, John Anderson4,5, Mette Jorgensen5, G. A. Amos Burke2,3, Johannes Visser2, James C. Nicholson2,3, Naima Smeulders5, Imran Mushtaq5, Grant D. Stewart2,8, Peter J. Campbell1, David C. Wedge12,13, Iñigo Martincorena1, Dyanne Rampling5, Liz Hook2,9, Anne Y. Warren2,9, Nicholas Coleman2,9, Tanzina Chowdhury5, Neil Sebire4,5, Jarno Drost14, Kourosh Saeb-Parsy2,8, Michael R. Stratton1, Karin Straathof4,5, Kathy Pritchard-Jones4,5, Sam Behjati1,2,3,*
Science  06 Dec 2019: Vol. 366, Issue 6470, pp. 1247-1251
https://science.sciencemag.org/content/366/6470/1247

6.Nature：诊断乳腺癌 人工智能完胜人类专家！
http://news.bioon.com/article/6748708.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
乳腺癌筛查AI系统的国际评估
McKinney, S.M., Sieniek, M., Godbole, V. et al. International evaluation of an AI system for breast cancer screening. Nature 577, 89–94 (2020) doi:10.1038/s41586-019-1799-6
https://www.nature.com/articles/s41586-019-1799-6

7.Nature：揭示摄入更多乳酸的黑色素瘤细胞是转移高手
http://news.bioon.com/article/6748361.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
代谢异质性赋予黑色素瘤转移潜能差异
Alpaslan Tasdogan et al. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature, 2019, doi:10.1038/s41586-019-1847-2.
https://www.nature.com/articles/s41586-019-1847-2

8.Cell：染色体外非编码DNA促进神经胶质瘤发生
http://news.bioon.com/article/6747050.html
http://www.kaseisyoji.com/forum. ... id=95264&page=1
功能增强子塑造染色体外致癌基因扩增
Cell Volume 179, Issue 6, 27 November 2019, Pages 1330-1341.e13
Article   Functional Enhancers Shape Extrachromosomal Oncogene Amplifications
https://www.sciencedirect.com/sc ... 19312164?via%3Dihub

9.Nature:重磅！科学家成功揭示肿瘤中环状染色体外DNA的结构与功能
http://news.bioon.com/article/6747044.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D3
环状ecDNA促进染色质的可及性和高癌基因表达
Wu， S.， Turner， K.M.， Nguyen， N. et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature (2019) doi：10.1038/s41586-019-1763-5
https://www.nature.com/articles/s41586-019-1763-5
染色体外致癌基因扩增驱动肿瘤进化和遗传异质性
Turner， K.， Deshpande， V.， Beyter， D. et al. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature 543， 122–125 (2017) doi：10.1038/nature21356
https://www.nature.com/articles/nature21356

10.Nature等：揭示促进癌症扩散的生存技能！
http://news.bioon.com/article/6745675.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D5
E-钙黏着蛋白是乳腺癌多种模型转移所必需的
Veena Padmanaban， Ilona Krol， Yasir Suhail， et al. E-cadherin is required for metastasis in multiple models of breast cancer， Nature (2019) doi：10.1038/s41586-019-1526-3
https://www.nature.com/articles/s41586-019-1526-3

11.Nature：重磅！揭示癌症中RNA改变的分子特征！
http://news.bioon.com/article/6750096.html
http://www.kaseisyoji.com/forum. ... id=80396&extra=
癌症中RNA改变的基因组基础
Calabrese, C., Davidson, N.R., Demircioğlu, D. et al. Genomic basis for RNA alterations in cancer. Nature 578, 129–136 (2020). doi：10.1038/s41586-020-1970-0
https://www.nature.com/articles/s41586-020-1970-0

12.Nature：首个系统性癌症基因组图谱问世——揭示癌细胞演化之谜
http://news.bioon.com/article/6750110.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95281
2,658种癌症的进化史
The evolutionary history of 2,658 cancers, Nature (2020). DOI: 10.1038/s41586-019-1907-7 ,
https://www.nature.com/articles/s41586-019-1907-7

13.Cancer：植物来源药物可用于治疗头颈癌
http://news.bioon.com/article/6750171.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95285
APG-157在口腔癌中的随机1期安慰剂对照试验表明，该药具有系统吸收作用，并对细胞因子和肿瘤相关微生物具有抑制作用
Saroj K. Basak et al, A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated microbes, Cancer (2020). DOI: 10.1002/cncr.32644
https://www.ncbi.nlm.nih.gov/pubmed/32022261

14.Science：细胞间通讯如何导致白血病发生？
http://news.bioon.com/article/6750158.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95286
科学家发现细胞之间的流氓通信如何导致白血病
Scientists discover how rogue communications between cells lead to leukemia
https://medicalxpress.com/news/2 ... cells-leukemia.html

15.Nature：重大进展！新研究揭示最常见的SF3B1基因突变如何导致癌症
http://news.bioon.com/article/6745227.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D5
非典型BAF复合体的剪接破坏
Daichi Inoue et al. Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature, 2019, doi:10.1038/s41586-019-1646-9.
https://www.nature.com/articles/s41586-019-1646-9

16.《细胞》:中国学者国际上率先揭示肝癌分子特征全景和个性化诊治新策略
https://www.thepaper.cn/newsDetail_forward_4629110
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
https://www.cell.com/cell/fullte ... 37%3Fshowall%3Dtrue

17.Nature：真菌感染与胰腺癌发生之间的关系
http://news.bioon.com/article/6744684.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
真菌菌群通过激活MBL促进胰腺癌发生
Berk Aykut, Smruti Pushalkar, Ruonan Chen, Qianhao Li, Raquel Abengozar, Jacqueline I. Kim, Sorin A. Shadaloey, Dongling Wu, Pamela Preiss, Narendra Verma, Yuqi Guo, Anjana Saxena, Mridula Vardhan, Brian Diskin, Wei Wang, Joshua Leinwand, Emma Kurz, Juan A. Kochen Rossi, Mautin Hundeyin, Constantinos Zambrinis, Xin Li, Deepak Saxena, George Miller. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature, 2019; DOI: 10.1038/s41586-019-1608-2
https://www.nature.com/articles/s41586-019-1608-2

18.自然-化学:大肠杆菌素致癌机制获破解
http://paper.sciencenet.cn/htmlp ... 61455554152675.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
大环大肠菌素通过铜介导的氧化裂解诱导DNA双链断裂
https://www.nature.com/articles/s41557-019-0317-7

19.Science重大进展：科学家们发现肿瘤形成的原子驱动力
http://news.bioon.com/article/6742449.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
Mengzhao Xue et al. Structure elucidation of colibactin and its DNA cross-links， Science (2019). DOI： 10.1126/science.aax2685
http://science.sciencemag.org/lookup/doi/10.1126/science.aax2685

20.Nature：重磅！癌症新伎俩！癌细胞产生更多的Win，并让邻近的健康细胞产生更多的Lose，促进癌症生长
http://news.bioon.com/article/6741757.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
花同工型促进癌症的竞争性增长
Esha Madan et al. Flower isoforms promote competitive growth in cancer. Nature, 2019, doi:10.1038/s41586-019-1429-3.
https://www.nature.com/articles/s41586-019-1429-3

21.Nature：蛋白过度表达可能是癌细胞的致命弱点
http://news.bioon.com/article/6741706.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
Hung-Ji Tsai et al. Hypo-osmotic-like stress underlies general cellular defects of aneuploidy， Nature (2019). DOI： 10.1038/s41586-019-1187-2
https://www.nature.com/articles/s41586-019-1187-2

22.Science：打破传统！癌症基因组中的突变“热点”不一定会推动癌症的生长！
http://news.bioon.com/article/6740678.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Michael S. Lawrence et al. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science (2019). DOI： 10.1126/science.aaw2872
https://science.sciencemag.org/content/364/6447/eaaw2872

23.Nature：科学家有望实现让疲惫不堪的免疫细胞重新焕发活力 再次高效抑制癌症进展
http://news.bioon.com/article/6740600.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Omar Khan, Josephine R. Giles, Sierra McDonald, et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion, Nature (2019). DOI:10.1038/s41586-019-1325-x
https://www.nature.com/articles/s41586-019-1325-x

24.Science：重大突破！以前仅作为一种疾病生物标志物，如今发现CA19-9导致胰腺炎和胰腺癌产生
http://news.bioon.com/article/6740364.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
D.D. Engle el al.The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Science, 2019, doi:10.1126/science.aaw3145.
https://science.sciencemag.org/content/364/6446/1156
C.J. Halbrook el al. Hiding in plain sight. Science, 2019, doi:10.1126/science.aax9341.
https://science.sciencemag.org/content/364/6446/1132

25.Nature：挑战常规！FOXA1以三种不同方式化身为癌基因，促进癌症产生
http://news.bioon.com/article/6740393.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Abhijit Parolia et al. Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Nature, 2019, doi:10.1038/s41586-019-1347-4.
https://www.nature.com/articles/s41586-019-1347-4

26.Nature：中国科学家揭示尿苷二磷酸葡萄糖抑制肺癌转移  糖醛酸代谢中间物
http://news.bioon.com/article/6740376.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Xiongjun Wang et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature, 2019, doi:10.1038/s41586-019-1340-y.
https://www.nature.com/articles/s41586-019-1340-y

27.《自然》:科学家揭示乳腺癌细胞转移机制  有望为预防癌症复发提供新法
http://paper.sciencenet.cn/htmlp ... 10305854552422.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
E-cadherin is required for metastasis in multiple models of breast cancer
https://www.nature.com/articles/s41586-019-1526-3

28.Nat Commun：揭示癌细胞转移的最佳路径
http://news.bioon.com/article/6744136.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
Matthew R. Zanotelli et al. Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making， Nature Communications (2019). DOI： 10.1038/s41467-019-12155-z
https://www.nature.com/articles/s41467-019-12155-z

29.Science：发现五种基因能让健康细胞癌变
抑癌53RB损,肺前膀小细胞基表似
http://news.bioon.com/article/6728438.html
http://www.kaseisyoji.com/forum. ... id=80527&extra=

30.Nature：重磅！科学家成功解析出转移性乳腺癌的基因组特性！
http://news.bioon.com/article/6739034.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D12
Francois Bertucci, Charlotte K. Y. Ng, Anne Patsouris, et al,. Genomic characterization of metastatic breast cancers, Nature 569, 560–564 (2019) doi:10.1038/s41586-019-1056-z
https://www.nature.com/articles/s41586-019-1056-z

31.Cell:新研究揭示抗感染与抗癌症的新机制
http://news.bioon.com/article/6738965.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Weina Zhang et al, Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS, Cell (2019). DOI: 10.1016/j.cell.2019.05.003
https://www.sciencedirect.com/sc ... 1930501X?via%3Dihub

32.Nature：来自中枢神经系统的神经祖细胞促进癌症中的神经发生
http://news.bioon.com/article/6738819.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Philippe Mauffrey et al. Progenitors from the central nervous system drive neurogenesis in cancer. Nature, 2019, doi:10.1038/s41586-019-1219-y.
https://www.nature.com/articles/s41586-019-1219-y

33.Nature：科学家锁定癌症相关蛋白质，有望延缓癌症进展
http://ctxy.bioon.com/xy/article_pc.html?id=6738594
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Dmitry I. Gabrilovich et al. Fatty acid transporter 2 reprograms neutrophils in cancer， Nature (2019). DOI： 10.1038/s41586-019-1118-2
https://www.nature.com/articles/s41586-019-1118-2

34.Nature：糖皮质激素促进乳腺癌转移
http://news.bioon.com/article/6735356.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid94539
Milan M. S. Obradović et al. Glucocorticoids promote breast cancer metastasis. Nature, 2019, doi:10.1038/s41586-019-1019-4.
https://www.nature.com/articles/s41586-019-1019-4

35.Nature：科学家成功揭示癌症的代谢成瘾特性
http://news.bioon.com/article/6737526.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Sudhir Chowdhry, Ciro Zanca, Utkrisht Rajkumar, et al. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling, Nature (2019). DOI: 10.1038/s41586-019-1150-2
https://www.nature.com/articles/s41586-019-1150-2

36.欧洲癌症杂志:哪些生活习惯会致癌? 胖晒病毒宫口肛癌
http://ctxy.bioon.com/xy/article_pc.html?id=6721281
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16

37.Cell：大规模乳腺癌细胞组成分析带来新型治疗方法
http://ctxy.bioon.com/xy/article_pc.html?id=6737368
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Johanna Wagner et al, A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer, Cell (2019). DOI: 10.1016/j.cell.2019.03.005
https://www.cell.com/cell/fullte ... 73%3Fshowall%3Dtrue

38.Cell：通过构建胰腺癌干细胞分子依赖性图谱，揭示胰腺癌治疗新策略
http://ctxy.bioon.com/xy/article_pc.html?id=6737185
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Nikki K. Lytle et al. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell, 2019, doi:10.1016/j.cell.2019.03.010.
https://www.cell.com/cell/fullte ... 27%3Fshowall%3Dtrue

39.《自然》：面对癌症之王 中美科学家们联合找到了诊疗新思路
http://news.bioon.com/article/6737168.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16

40.Nature：DNA解旋酶WRN是微卫星不稳定性癌症的一种合成致死性靶标
http://news.bioon.com/article/6737234.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Edmond M. Chan et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers, Nature (2019). DOI: 10.1038/s41586-019-1102-x.
https://www.nature.com/articles/s41586-019-1102-x

41.Nature：大规模CRISPR/Cas9筛选鉴定出600个癌症基因靶标
http://news.bioon.com/article/6737243.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D17
Fiona M. Behan et al. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens. Nature, 2019, doi:10.1038/s41586-019-1103-9.
https://www.nature.com/articles/s41586-019-1103-9

42.Cell：新研究揭示环境致癌物的独特突变特征 , 有助揭示癌症病因  
http://news.bioon.com/article/6737183.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D17
Jill E. Kucab et al, A Compendium of Mutational Signatures of Environmental Agents, Cell (2019). DOI: 10.1016/j.cell.2019.03.001.
https://www.cell.com/cell/fullte ... 36%3Fshowall%3Dtrue

43.Nature：靶向胰腺癌致命弱点取得令人鼓舞的结果
http://news.bioon.com/article/6737143.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D17
Yu Shi et al. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature, 2019, doi:10.1038/s41586-019-1130-6.
https://www.nature.com/articles/s41586-019-1130-6

44.Science：揭示肿瘤抑制基因BAP1失活为何仅促进肿瘤在特定组织中形成
http://news.bioon.com/article/6737134.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D17
Meng He et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science, 2019, doi:10.1126/science.aav4902.
https://science.sciencemag.org/content/364/6437/283

45.Cell：新研究表明细菌可促进肺肿瘤产生
http://news.bioon.com/article/6733433.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D18
Chengcheng Jin et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell, 2019, doi:10.1016/j.cell.2018.12.040.
https://www.cell.com/cell/fullte ... 44%3Fshowall%3Dtrue

46.Nature：发现p38γ是肝癌的一个新的治疗靶标
http://news.bioon.com/article/6736692.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D18
Antonia Tomás Loba et al. p38γ is essential for cell cycle progression and liver tumorigenesis. Nature, 2019, doi:10.1038/s41586-019-1112-8.
https://www.nature.com/articles/s41586-019-1112-8

47.《细胞》：科学家确认癌细胞可“远程缴械”免疫系统
http://paper.sciencenet.cn/htmlp ... 01328726649887.shtm
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D18
相关论文信息：DOI:https://doi.org/10.1016/j.cell.2019.02.016
https://www.cell.com/cell/fulltext/S0092-8674(19)30165-5#

48.Nature：解析特殊代谢酶的3D结构 有望帮助开发新型癌症疗法
http://news.bioon.com/article/6736528.html  
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D18
Jia Wei, Silvana Leit, Jun Kuai, et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature, 2019 DOI:10.1038/s41586-019-1094-6
https://www.nature.com/articles/s41586-019-1094-6

49.Nature：研究发现各种癌症组织中广泛存在的致癌组蛋白！
http://news.bioon.com/article/6736062.html  
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D19
Benjamin A. Nacev et al. The expanding landscape of 'oncohistone' mutations in human cancers, Nature (2019). DOI: 10.1038/s41586-019-1038-1
https://www.nature.com/articles/s41586-019-1038-1

50.《Nature Cell Biology》：一半癌症里都有它！科学家找到一种抗癌新策略  p53
http://news.bioon.com/article/6735654.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D20

51.Science：如何有效改善儿童癌症患者的精准化治疗？
http://news.bioon.com/article/6735595.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D21
E. Alejandro Sweet-Cordero, Jaclyn A. Biegel. The genomic landscape of pediatric cancers: Implications for diagnosis and treatment. Science, 2019; 363 (6432): 1170 DOI: 10.1126/science.aaw3535
http://science.sciencemag.org/content/363/6432/1170

52.Cell：癌症的主要突变模式是突发性的
http://news.bioon.com/article/6735606.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D21
Mia Petljak et al. Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis. Cell, 2019, doi:10.1016/j.cell.2019.02.012.
https://www.cell.com/cell/fullte ... 18%3Fshowall%3Dtrue

53.Nature：揭示乳腺癌细胞转移新机制
http://news.bioon.com/article/6735035.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D22
Ilaria Elia et al. Breast cancer cells rely on environmental pyruvate to shape the metastatic niche. Nature, 2019, doi:10.1038/s41586-019-0977-x.
https://www.nature.com/articles/s41586-019-0977-x

54.Nature：新研究揭示为何癌症最常扩散到肝脏
http://news.bioon.com/article/6734939.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D22
Jae W. Lee et al. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature, 2019, doi:10.1038/s41586-019-1004-y.
https://www.nature.com/articles/s41586-019-1004-y

55.Nat Med重磅！新联合疗法显著抑制胰腺癌生长！
http://ctxy.bioon.com/xy/article_pc.html?id=6734883
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D22
Conan Kinsey and Martin McMahon et al. Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers, Nature Medicine (2019). DOI: 10.1038/s41591-019-0367-9

56.《自然》：中国科学家发现肝细胞癌精准治疗潜在新靶点
http://paper.sciencenet.cn/htmlp ... 11192676749412.shtm
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D22
相关论文信息：https://doi.org/10.1038/s41586-019-0987-8
https://www.nature.com/articles/ ... =news.sciencenet.cn
https://www.nature.com/articles/s41586-019-0987-8

57.《自然》：破解肿瘤劫持神经细胞之谜 让科学家发现了降血压药的抗癌潜力
http://news.bioon.com/article/6750468.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95297

58.Science：癌细胞通过增加核糖体蛋白产生来促进乳腺癌转移
http://news.bioon.com/article/6750422.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95299
Richard Y. Ebright et al. Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis. Science, 2020, doi:10.1126/science.aay0939.
https://science.sciencemag.org/c ... /05/science.aay0939

59.《科学》 ：“小剪刀”有望对癌症下手
http://paper.sciencenet.cn/htmlp ... 15414372654844.shtm
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95305
https://science.sciencemag.org/c ... /05/science.aba7365

60.Nature：遗传印迹揭示导致癌症发生的肠道微生物
http://news.bioon.com/article/6751186.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95319
Pleguezuelos-Manzano C., Puschhof J. et al. 2020. A mutational signature in human colorectal cancer induced by genotoxic pks+ E. coli. Nature. DOI: 10.1038/s41586-020-2080-8
https://www.nature.com/articles/s41586-020-2080-8

61.Science等：万万没想到，癌症和心脏病竟然可以传染！
http://news.bioon.com/article/6751796.html
http://www.kaseisyoji.com/forum. ... id=80458&extra=
https://science.sciencemag.org/content/367/6475/250

62.《细胞》:补体调控肿瘤相关B细胞的双向作用 促抗肿瘤
http://paper.sciencenet.cn/htmlp ... 22135039555348.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
https://www.cell.com/cell/fulltext/S0092-8674(20)30159-8

63.Nature:AI增强版“滴血测癌”,准确率高达86%! 微生物DNA
http://tech.sina.com.cn/csj/2020-03-12/doc-iimxxstf8430900.shtml
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
https://www.nature.com/articles/s41586-020-2095-1

64.Science重磅：发现15个引发头颈部鳞状细胞癌快速生长的基因
http://news.bioon.com/article/6752035.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95346
https://science.sciencemag.org/content/367/6483/1264

65.两篇Nature文章深度解读保护机体免于癌症的关键细胞机制！ 细胞凋亡
http://news.bioon.com/article/6754824.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95408
https://www.nature.com/articles/s41586-020-2187-y
https://www.nature.com/articles/s41586-020-2182-3

66.Science：血液测试有助于在症状出现之前发现癌症 1/4
http://news.bioon.com/article/6755054.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95415
https://medicalxpress.com/news/2020-04-blood-cancer-symptoms.html

67.《自然》:新方法让你看到细胞癌变 有丝分裂荧光LEM2蛋白
http://news.bioon.com/article/6755018.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95417

68.Nature：子宫内膜在生命早期就开始产生致癌突变！ 3到6驱动突变 几十年
http://news.bioon.com/article/6754448.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
https://www.nature.com/articles/s41586-020-2214-z

69.Nature：揭示身体如何检测癌症早期征兆 微核 炎症
http://news.bioon.com/article/6707577.html
https://www.nature.com/articles/ ... mp;draft=collection
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D88

70.《科学》封面：人类肿瘤里发现大量细菌
http://news.bioon.com/article/6756418.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95453

71.Nature：肿瘤代谢产物阻碍DNA修复！原因在于局部染色体信号扰乱！ 琥珀酸延胡戊二
http://news.bioon.com/article/6756700.html
https://www.nature.com/articles/d41586-020-01569-1
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95465

72.Nature：揭示CDK抑制剂CR8作为分子胶水降解剂杀死癌细胞  酶降解蛋白质
http://news.bioon.com/article/6757186.html
https://www.nature.com/articles/s41586-020-2374-x
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95479

73.PNAS：发现“终结者”蛋白可以阻止癌细胞的产生！ 抑癌基因
http://news.bioon.com/article/6757295.html
https://www.pnas.org/content/117/24/13447
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95480

74.Nature：警惕！阳光造成的DNA损伤很难修复！ 调节区高度易突变 不易修复
http://news.bioon.com/article/6724990.html
https://medicalxpress.com/news/2018-07-sun-safe-dna.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95489

75.Nature：揭示化学物质导致复杂细胞突变和癌变的机制！  烟废植D突癌
http://news.bioon.com/article/6757887.html
https://www.nature.com/articles/s41586-020-2435-1
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

76.《科学》：“相分离”现象使抗癌药物更有效 凝聚物液滴
http://paper.sciencenet.cn/htmlp ... 11164377557181.shtm
https://science.sciencemag.org/content/368/6497/1386
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95494

77.Nature：揭示裸鼹鼠抵抗癌症的新秘密 细胞微环境
http://news.bioon.com/article/6758486.html
https://www.nature.com/articles/s41586-020-2410-x
https://medicalxpress.com/news/2 ... cer-resistance.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95505

78.Cell解读！迄今为止最全面的研究揭示非吸烟人群患肺癌的生物学特性和发病机制！  多样化环境致癌突变遗传
http://news.bioon.com/article/6759475.html
https://www.cell.com/cell/fullte ... 31%3Fshowall%3Dtrue
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95533

79.Nature重大突破！肺癌精准治疗临床试验取得成功  药精准针对基因组治
http://news.bioon.com/article/6758992.html
https://www.nature.com/articles/s41586-020-2481-8
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95576

80.Nature：如何通过轻松按下代谢开关就能有效减缓肿瘤的生长和进展？   限丝氨酸甘氨酸 抑酶
http://news.bioon.com/article/6777169.html
https://www.nature.com/articles/s41586-020-2609-x
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95575

81.Cell：液体样品检测可用于癌症的诊断 癌细胞外囊泡和颗粒
http://news.bioon.com/article/6777187.html
https://www.cell.com/cell/fullte ... 20308746%3Fshowall%
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95577

82.Nature：诸如红茶、巧克力和浆果等富含抗氧化剂的食物或会增加结直肠癌的患病风险
http://news.bioon.com/article/6759675.html
https://www.nature.com/articles/s41586-020-2541-0
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95578

83.《自然》：科学家揭示癌症免疫逃逸的新机制  抑癌吸蛋氨酸 助T细胞
http://paper.sciencenet.cn/htmlp ... 13304850458461.shtm
https://www.nature.com/articles/s41586-020-2682-1
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95585

84.Cell：揭示失控的cAMP分子诱发肝癌的分子机制  无膜细胞器似油滴
http://news.bioon.com/article/6778142.html
https://www.cell.com/cell/fullte ... 10%3Fshowall%3Dtrue
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95592

85.Nature：科学家深入解析淋巴结如何帮助癌细胞发生扩散？  油酸保护膜抗血氧化
https://www.bioon.com/article/6777958.html
https://www.nature.com/articles/s41586-020-2623-z
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95624

86.Cancer Res：不可思议！生长激素水平的升高或会增加机体患多种癌症的风险！  
较高水平的乳制品摄入或会增加机体中IFG-1的浓度
https://news.bioon.com/article/6778527.html
https://cancerres.aacrjournals.org/content/80/18/4014
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95625

87.Nature：研究揭示癌细胞扩散新机制  内皮神经Slit2癌入血
https://news.bioon.com/article/6779084.html
https://www.nature.com/articles/s41586-020-2774-y
https://medicalxpress.com/news/2 ... lls-nerve-cell.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95650

88.Science：生物学与物理学的结合帮助揭示癌症的本质  变害长避血移 固压液压刚度微构
https://news.bioon.com/article/6780239.html
https://science.sciencemag.org/content/370/6516/eaaz0868.full
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95667

89.Cell解读！揭秘神经组织如何保证胰腺癌细胞免于饥饿影响？  神生长子轴突丝氨酸
https://news.bioon.com/article/6781012.html
https://www.cell.com/cell/fullte ... 22%3Fshowall%3Dtrue
https://www.sciencedirect.com/sc ... i/S0092867420313222
http://www.kaseisyoji.com/forum. ... &extra=page%3D4
https://medicalxpress.com/news/2 ... cells-starving.html

90.Nature子最新研究｜通过长达10年时间监测，被公认为安全的AAV载体存在潜在致癌性  肝癌
https://news.bioon.com/article/6781343.html
https://www.nature.com/articles/s41587-020-0741-7
https://www.sciencemag.org/news/ ... isk-dog-study-hints
https://www.nature.com/articles/s41576-019-0205-4
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95695

顾汉现

不生癌（一生中从不生癌、终生不生癌，并包括临床治癒后不复发） 主要参考文献 续

91.Cell：“畸胎瘤”有望作为科学家研究人类发育过程的理想模型 胎儿 3胚层
https://news.bioon.com/article/6780565.html
https://www.sciencedirect.com/sc ... i/S0092867420313817
https://www.cell.com/cell/fullte ... 17%3Fshowall%3Dtrue
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95710

92.Nature解读！科学家们揭示诱发淋巴瘤的关键基因突变！ B细胞组蛋白H1突变
http://news.bioon.com/article/6782248.html
https://www.nature.com/articles/s41586-020-3017-y
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

93.Nature：揭示染色体碎裂导致癌细胞耐药性机制  重组携带促癌基因联药
http://news.bioon.com/article/6782418.html
https://www.nature.com/articles/s41586-020-03064-z
https://medicalxpress.com/news/2 ... drug-resistant.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95729

94.Nature：癌细胞在规避免疫系统时竟会出卖自己的行踪 色氨酸 癌
http://news.bioon.com/article/6782213.html
https://www.nature.com/articles/s41586-020-03054-1
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95733

95.Nature：首张癌症转移图谱出炉 涉及21个癌种500株人癌细胞系  多基突变
http://news.bioon.com/article/6782075.html
http://news.bioon.com/article/6781912.html
https://www.nature.com/articles/s41586-020-2969-2
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95740

96.Nature：新型癌症治疗策略！新型小分子抑制剂高度选择性破坏癌细胞中的线粒体功能  抑线粒体DNA复制
http://news.bioon.com/article/6782136.html
https://www.nature.com/articles/s41586-020-03048-z
https://medicalxpress.com/news/2 ... eatment-effect.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95752

97.难怪癌症那么难治！《细胞》研究发现，癌细胞竟会全体“冬眠”躲过化疗
https://www.linkresearcher.com/t ... 6-ba64-1ab25b862c75
https://www.cell.com/cell/fullte ... 5X%3Fshowall%3Dtrue
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95763

98.Nature：突破！揭示基因与环境因素“合谋”推动胰腺癌发生的分子机理！ 酶伤炎表K突变癌
http://news.bioon.com/article/6783853.html
https://www.nature.com/articles/s41586-020-03147-x
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95791

99.Nature：科学家成功利用机器学习技术对肺癌患者进行早期诊断  血液癌DNA
https://www.nature.com/articles/s41586-020-2140-0
https://news.bioon.com/article/6753136.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95803

100.Nature：揭示在健康的肝脏中发现的DNA突变积累会导致慢性肝病和肝癌
https://www.nature.com/articles/s41586-019-1670-9
https://news.bioon.com/article/6748307.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95846
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.31211

101.《科学》：解开癌细胞“能量工厂”的百年难题  酵解加速细胞分裂
https://science.sciencemag.org/content/371/6527/405
http://paper.sciencenet.cn/htmlp ... 10235924661004.shtm
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95847

102.《自然》：染色体碎裂促进癌症中基因扩增的进化 耐药
https://www.nature.com/articles/s41586-020-03064-z
http://news.sciencenet.cn/htmlpa ... 51253469760413.shtm
https://www.linkresearcher.com/t ... c-8bab-829546dbdae6
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95885

103.Nature重磅！诺奖得主揭示“另类”潜在抑癌方法：把癌细胞“挤”出去
https://www.nature.com/articles/s41586-021-03526-y
http://news.bioon.com/article/6786929.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2

104.Nature：新发现！科学家揭示有效预防癌症转移的新机制！  γ自然杀伤细胞休眠癌细胞
https://www.nature.com/articles/s41586-021-03614-z
http://news.bioon.com/article/6787793.html
http://news.bioon.com/article/6787913.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

105.Science:一种古老的抗抑郁药可以帮助免疫系统对抗老鼠体内的肿瘤  增多巴胺和5-羟色胺，“勇士”   单胺氧化酶抑制剂抑癌
https://www.sciencemag.org/news/ ... m-fight-tumors-mice
http://news.bioon.com/article/6787593.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

106.Nature：新研究可实时观察癌症如何进化  化疗 适者生存
https://www.nature.com/articles/s41586-021-03648-3
http://news.bioon.com/article/6788844.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96005

107.《自然》：肝癌创新组合疗法有望克服耐药问题 复合
https://www.nature.com/articles/s41586-021-03741-7
https://www.linkresearcher.com/t ... d-b33e-b3eeaf989271
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96025

108.《自然》连发4篇论文：基因突变如何塑造出我们？  突变修复  不一定会导致癌症
突变指纹编码细胞历史
https://www.nature.com/articles/d41586-021-02269-0
人类体细胞和生殖细胞的突变景观
https://www.nature.com/articles/s41586-021-03822-7
形态正常人体组织中体细胞诱变的身体图谱
https://www.nature.com/articles/s41586-021-03836-1
从体细胞突变推断出人类发展的广泛系统发育
https://www.nature.com/articles/s41586-021-03790-y
从体细胞突变推断早期人类胚胎发生的克隆动力学
https://www.nature.com/articles/s41586-021-03786-8
https://www.linkresearcher.com/t ... e-8608-910b9dc60477
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96090

109.Nat子:抗癌新招数！简单升温，就能轻松唤醒抗癌大军  40-42℃
https://www.nature.com/articles/s41551-021-00781-2
https://www.linkresearcher.com/t ... c-89e1-54f667431713
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96096

110.《科学》:发育染色质程序决定黑色素瘤的致癌能力  开启基因
https://www.science.org/doi/10.1126/science.abc1048
https://www.eurekalert.org/news-releases/926714
https://www.linkresearcher.com/t ... 1-8125-12421e4cf014
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96100

110.为什么有些免疫细胞更擅长杀死癌细胞？《自然》揭示提高免疫应答的关键
黑色素瘤中抗肿瘤 CD8 + T 细胞的表型、特异性和亲和力  特异感癌T胞不耗竭
https://www.nature.com/articles/s41586-021-03704-y
https://www.linkresearcher.com/t ... c-a48b-21a0d146d0c2
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96142

111.《自然》:肿瘤里竟藏着一支抗癌大军 抗原特异性T细胞 疫苗  头颈癌中的功能性HPV特异性PD-1 +干细胞样CD8 T细胞
https://www.nature.com/articles/s41586-021-03862-z
https://www.linkresearcher.com/t ... 8-b1d9-881e6c341905
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96145

112.Nature：利用人工智能有望帮助临床医生做出更好的癌症治疗决定  区分致命扩散基因组
https://www.nature.com/articles/s41586-021-03922-4
http://news.bioon.com/article/6791391.html
http://www.kaseisyoji.com/forum. ... id=96160&page=1

113.三篇《科学》齐发：科学家对癌症发病有了新的认识  头颈癌的蛋白质 乳腺癌的蛋白质
https://www.linkresearcher.com/t ... d-8799-c287cfd84565
https://www.science.org/doi/10.1126/science.abf2911
https://www.science.org/doi/epdf/10.1126/science.abf3066
https://www.science.org/doi/10.1126/science.abf3067
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96169

114.Nature：这种致死率最高的恶性肿瘤，或将迎来精准治疗时代  突变-药敏精
https://www.nature.com/articles/s41586-021-03898-1
https://www.linkresearcher.com/t ... a-8bbb-73bf1543f6de
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96170

115.《自然》：热量限制可抑制肿瘤生长  降血脂血糖抑癌
https://www.nature.com/articles/s41586-021-04049-2
http://paper.sciencenet.cn/htmlp ... 01704987067251.shtm
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96202
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

116.Science：揭示细胞毒性T细胞如何重新装上武器，进行一次又一次的杀戮  摧毁癌细胞和受到病毒感染的细胞  细胞毒性 T 细胞持续杀伤需要线粒体翻译
https://www.science.org/doi/10.1126/science.abe9977
http://news.bioon.com/article/6791892.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96207

117.《自然》：最凶险的乳腺癌为何难治？华人团队揪出关键线索  DDR1的分子
https://www.nature.com/articles/s41586-021-04057-2
https://www.linkresearcher.com/t ... d-9bf1-0f3b2445a8a3
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96255

118.Science：分解蛋白质供能，饥饿的癌细胞是如何转换“食物”来源的？
https://www.science.org/doi/10.1126/science.abn5637
https://news.bioon.com/article/54bee39490ee.html
https://www.linkresearcher.com/t ... 1-acba-ab7e6abb191a
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

119.《自然》：打造转移的“发动机”，癌细胞竟是这样做的！ 线粒体
https://www.nature.com/articles/s41586-022-04898-5
https://news.bioon.com/article/1c4fe36140e1.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

120.《自然》惊奇大发现！经典癌基因可以产生奇怪小球，实实在在保卫癌细胞 蛋白
https://www.nature.com/articles/s41586-022-05469-4
https://www.linkresearcher.com/t ... a-8bd5-46d3bef0dec1
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96757

121.Nature：肺部分泌的因子发生年龄相关变化导致休眠的黑色素瘤重新激活和生长机制 WNT5A
https://www.nature.com/articles/s41586-022-04774-2
https://news.bioon.com/article/6b7be287761f.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96611

122.《自然》：刷新认知！科学家首次发现，肿瘤中的微生物不是随机分布的，而是高度组织化的  侵袭免抑
Nature:Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
https://news.bioon.com/article/2bc5e59222b3.html
https://www.nature.com/articles/s41586-022-05435-0
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

123.EB病毒感染了全世界90%的人，涉嫌多种癌症，《自然》新研究揭示它如何致癌
https://www.nature.com/articles/s41586-023-05923-x
https://www.linkresearcher.com/t ... 7-b06d-899f36fbd687

124.自然:结直肠癌和膀胱癌症等对男性更致命 和Y染色体有关
https://www.nature.com/articles/s41586-023-06234-x
https://paper.sciencenet.cn/html ... 15224363482934.shtm
https://www.linkresearcher.com/t ... 8-aa18-bdd477430539

125.Nature：发现癌细胞中线粒体发挥功能的关键信息 能量代谢
https://www.nature.com/articles/s41586-023-05793-3
https://news.bioon.com/article/1409e631623e.html

126.癌细胞嚣张！《自然》重磅论文，癌细胞不仅懒还很节俭
https://www.nature.com/articles/s41586-022-05661-6
https://www.linkresearcher.com/t ... b-8162-c822f3feb43c

127.癌症发生并非毫无征兆，《自然》新发现有望从源头杀死癌细胞  检测基因变化 TP53缺失
https://www.nature.com/articles/s41586-023-06102-8
https://www.linkresearcher.com/t ... 9-8077-3f33a3035ec3

128.Nature：新研究揭示表观遗传调控在癌症形成、生长和扩散过程中起着重要作用
https://news.bioon.com/article/f1fde9908537.html
Nature：Epigenetic regulation during cancer transitions across 11 tumour types
https://www.nature.com/articles/s41586-023-06682-5

129.Nature：震惊！胶质瘤劫持大脑可塑性机制来促进自身生长
https://www.nature.com/articles/s41586-023-06678-1
https://news.bioon.com/article/8d4ee990866c.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96995

130.《科学》：液体活检重大突破！提前发现微小肿瘤，灵敏度从不足10%提高到75%以上
https://www.linkresearcher.com/t ... 6-829f-ce7400896be6
Science : Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies
https://www.science.org/doi/10.1126/science.adf2341

131.Nature：新研究揭示MRE11从核小体封锁中释放cGAS从而预防癌症产生的机制
https://news.bioon.com/article/56818088e494.html
Nature ： MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis
https://www.nature.com/articles/s41586-023-06889-6

133.《科学》：揭秘这个关键细胞过程，有望带来全新癌症疗法 微管 有丝分裂
https://www.linkresearcher.com/t ... f-8bea-c4ca3d52a142
Science: Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation
https://www.science.org/doi/10.1126/science.adk6160

134. Nature：不同细胞外基质组成对肿瘤发生的影响不同 致癌突变体SmoM2致稀疏的细胞外基质导致肿瘤发起和侵袭 而密集的I型胶原蛋白抑制肿瘤发生
https://www.linkresearcher.com/t ... f-b1f1-0166440b13a9
Nature: The extracellular matrix dictates regional competence for tumour initiation
https://www.nature.com/articles/s41586-023-06740-y

135.Nature : 生存率不足7%，致命肺癌为何易复发？《自然》揭示关键基因组变化
https://www.linkresearcher.com/t ... 6-833a-88d6a1edb9e5
Nature : Evolutionary trajectories of small cell lung cancer under therapy
https://www.nature.com/articles/s41586-024-07177-7

136.《自然》: 口腔里潜伏着这种癌症的“帮凶”！具核梭杆菌
https://www.linkresearcher.com/t ... 8-acad-060b926184d7
Nature : A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche
https://www.nature.com/articles/s41586-024-07182-w
http://www.kaseisyoji.com/forum. ... amp;extra=#pid97062

137.《自然》：生存率不足7%，致命小细胞肺癌易复发 等5篇
http://www.kaseisyoji.com/forum. ... &extra=page%3D1

138.Nature:3D基因组图谱揭示人类胰腺癌前病变的多灶性 等11篇
http://www.kaseisyoji.com/forum. ... id=82243&extra=

139.《科学》 : 癌细胞居然会沿脊椎爬进大脑！ 等4篇
http://www.kaseisyoji.com/forum. ... id=82255&extra=

140.自然：癌细胞是如何炼成的？TNF信号来源转换是关键 等7篇
http://www.kaseisyoji.com/forum. ... id=82259&extra=
http://www.fuaaj.org/bbs/viewthr ... &extra=page%3D1

141.復康牌癌症预防、营养提供、抗衰老美容、健康食品、保健機能食品
http://www.kaseisyoji.com/forum.php?mod=viewthread&tid=82267

142.復康牌 癌症､结节､息肉等预防、辅助支持配合治疗、营养提供、抗衰老美容防痴呆、健康食品、保健機能食品
http://www.kaseisyoji.com/forum. ... amp;extra=#pid97131

143.Nature：揭示卵巢老化的基因密码：稀有变异与癌症风险的双重关联 等6篇
1.Nature：揭示卵巢老化的基因密码：稀有变异与癌症风险的双重关联
https://news.bioon.com/article/2667843623af.html
http://www.fuaaj.org/bbs/viewthr ... &extra=page%3D1
http://www.kaseisyoji.com/forum. ... id=82270&extra=
https://www.nature.com/articles/s41586-024-07894-z

144.Nature：科学家识别出有望治疗人类三阴性乳腺癌的新型组合性疗法 等6篇
http://www.kaseisyoji.com/forum. ... amp;extra=#pid97138

各种主要参考著作：
现代肿瘤学
肿瘤学 新理论与新技术
临床用药指南
临床用药手册
治療薬マニュアル（治疗药物手册）
临床用药的药理学基础
新编药物学
药师手册
常用药物新用途临床大全
神经药理学
精神药理学
生物药剂学
现代中药药理手册
中药抗肿瘤有效成分药理与应用
中药大辞典
诊断学
今日の臨床検査
实用内科学
標準外科学
诸福堂实用儿科学
中华妇产科学
眼科全书
临床皮肤科学
清华译 生物学
分子细胞生物学
血液分子细胞生物学
医用微生物学
医用生物化学
医学遗传学
生物统计学
系统解剖学
人体生理学
体温生理学
病理学
神经科学
神经内分泌学
神经科学百科全书
睡眠医学 理论与实践
实用医学大辞典
实用营养学
特殊营养学
食品成分表
实用延年益寿学
衰老与老年病防治研究
现代穴位疗法大全
理科年表（日文）
诺贝尔奖获奖者全书

（小部分日美等网页、中国大陆看不了，一小部分大陆网页、节目，日美等看不了。）