Sci：新冠病毒变体抗原漂移影响 变种逃避抗体中和 疫苗研发

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近期新冠病毒变体中抗原漂移的结构和功能影响  

病毒变种逃避抗体中和。降抗体话性。

领研网

2021/08/22

论文
论文标题：Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
作者：Meng Yuan , Deli Huang , Chang-Chun D. Lee , Nicholas C. Wu , Abigail M. Jackson , Xueyong Zhu , Hejun Liu , Linghang Peng , Marit J. van Gils , Rogier W. Sanders , Dennis R. Burton , S. Momsen Reincke , Harald Prüss , Jakob Kreye , David Nemazee , Andrew B. Ward , Ian A. Wilson

期刊：Science
发表时间：2021/08/13
数字识别码：10.1126/science.abh1139
摘要：Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are generally less effective against recent variants of concern. RBS residues Glu484, Lys417, and Asn501 are mutated in variants first described in South Africa (B.1.351) and Brazil (P.1). We analyzed their effects on angiotensin-converting enzyme 2 binding, as well as the effects of two of these mutations (K417N and E484K) on nAbs isolated from COVID-19 patients. Binding and neutralization of the two most frequently elicited antibody families (IGHV3-53/3-66 and IGHV1-2), which can both bind the RBS in alternative binding modes, are abrogated by K417N, E484K, or both. These effects can be structurally explained by their extensive interactions with RBS nAbs. However, nAbs to the more conserved, cross-neutralizing CR3022 and S309 sites were largely unaffected. The results have implications for next-generation vaccines and antibody therapies.

所属学科：
生物
病毒学
基因组学
（导读 阿金）本研究分析了南非和巴西发现的新冠病毒变体中突变的受体结合位点（RBS）残基Glu484、Lys417和Asn501对血管紧张素转化酶2结合的影响，K417N突变和E484K突变对分离自新冠肺炎患者的中和抗体（nAbs）的影响。K417N和E484K可消除两类最常诱发抗体家族（IGHV3-53/3-66和IGHV1-2）的结合和中和活性。但是针对更保守、交叉中和的CR3022和S309位点的nAbs基本上不受影响。该结果有助于研发下一代疫苗和抗体治疗剂。

https://science.sciencemag.org/content/373/6556/818

https://www.linkresearcher.com/t ... 0-a0a8-859fbe285519



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