Nat:脑运动和恐惧回路在急性应激期间调节白细胞

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脑运动和恐惧回路在急性应激期间调节白细胞

神经系统和免疫系统错综复杂地联系在一起。

领研网

2022/08/01

论文
论文标题：Brain motor and fear circuits regulate leukocytes during acute stress
作者：Wolfram C. Poller, Jeffrey Downey, Agnes A. Mooslechner, Nargis Khan, Long Li, Christopher T. Chan, Cameron S. McAlpine, Chunliang Xu, Florian Kahles, Shun He, Henrike Janssen, et al.

期刊：Nature
发表时间：2022/05/30
数字识别码：10.1038/s41586-022-04890-z
摘要：The nervous and immune systems are intricately linked1. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly understood2. Here we show that distinct brain regions shape leukocyte distribution and function throughout the body during acute stress in mice. Using optogenetics and chemogenetics, we demonstrate that motor circuits induce rapid neutrophil mobilization from the bone marrow to peripheral tissues through skeletal-muscle-derived neutrophil-attracting chemokines. Conversely, the paraventricular hypothalamus controls monocyte and lymphocyte egress from secondary lymphoid organs and blood to the bone marrow through direct, cell-intrinsic glucocorticoid signalling. These stress-induced, counter-directional, population-wide leukocyte shifts are associated with altered disease susceptibility. On the one hand, acute stress changes innate immunity by reprogramming neutrophils and directing their recruitment to sites of injury. On the other hand, corticotropin-releasing hormone neuron-mediated leukocyte shifts protect against the acquisition of autoimmunity, but impair immunity to SARS-CoV-2 and influenza infection. Collectively, these data show that distinct brain regions differentially and rapidly tailor the leukocyte landscape during psychological stress, therefore calibrating the ability of the immune system to respond to physical threats.

所属学科：
神经医学
免疫学
医学

(导读 J.T.) 脑中压力网络与外周白细胞联系的机制尚不清楚。本研究发现，在小鼠急性应激期间，不同的大脑区域塑造了白细胞的分布和功能。运动回路通过来源骨骼肌、吸引中性粒细胞的趋化因子，诱导中性粒细胞从骨髓快速动员至周围组织。室旁下丘脑通过糖皮质激素信号控制单核细胞和淋巴细胞从二级淋巴器官和血液向骨髓排出。急性应激通过重塑中性粒细胞并招募它们至损伤部位来改变先天免疫力。促肾上腺素释放激素神经元介导的白细胞转移可防止获得自身免疫，但会损害对SARS-CoV-2和流感的免疫力。

文章标签
大脑压力网络
外周白细胞
神经元-血管相互作用
应激期

https://www.nature.com/articles/s41586-022-04890-z

https://www.linkresearcher.com/t ... 2-ba44-f7f793a8c2b1



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