Nat:微生物利用肠道上皮细胞死亡诱导的营养释放 生长

顾汉现

微生物利用肠道上皮细胞死亡诱导的营养释放  

凋亡细胞释放的代谢物充当组织信使 。 凋亡代谢物的混合物降低了疾病的严重程度。

领研网

2021/08/22

论文
论文标题：Microbes exploit death-induced nutrient release by gut epithelial cells
作者：Anderson, Christopher J., Medina, Christopher B., Barron, Brady J., Karvelyte, Laura, Aaes, Tania Løve, Lambertz, Irina, Perry, Justin S. A., Mehrotra, Parul, Gonçalves, Amanda, Lemeire, Kelly, Blancke, Gillian, Andries, Vanessa, Ghazavi, Farzaneh, Martens, Arne, van Loo, Geert, Vereecke, Lars, Vandenabeele, Peter, Ravichandran, Kodi S.

期刊：Nature
发表时间：2021/08/04
数字识别码：10.1038/s41586-021-03785-9
摘要：Regulated cell death is an integral part of life, and has broad effects on organism development and homeostasis1. Malfunctions within the regulated cell death process, including the clearance of dying cells, can manifest in diverse pathologies throughout various tissues including the gastrointestinal tract2. A long appreciated, yet elusively defined relationship exists between cell death and gastrointestinal pathologies with an underlying microbial component3,4,5,6, but the direct effect of dying mammalian cells on bacterial growth is unclear. Here we advance a concept that several Enterobacteriaceae, including patient-derived clinical isolates, have an efficient growth strategy to exploit soluble factors that are released from dying gut epithelial cells. Mammalian nutrients released after caspase-3/7-dependent apoptosis boosts the growth of multiple Enterobacteriaceae and is observed using primary mouse colonic tissue, mouse and human cell lines, several apoptotic triggers, and in conventional as well as germ-free mice in vivo. The mammalian cell death nutrients induce a core transcriptional response in pathogenic Salmonella, and we identify the pyruvate formate-lyase-encoding pflB gene as a key driver of bacterial colonization in three contexts: a foodborne infection model, a TNF- and A20-dependent cell death model, and a chemotherapy-induced mucositis model. These findings introduce a new layer to the complex host–pathogen interaction, in which death-induced nutrient release acts as a source of fuel for intestinal bacteria, with implications for gut inflammation and cytotoxic chemotherapy treatment.

所属学科：
微生物学
（导读 阿金）细胞受调节而死亡是生命过程的重要部分，对生物发育和内稳态产生重要影响。本研究提出一个新概念：若干肠杆菌科，包括来自患者的临床分离菌株，都具备有效的生长策略，利用即将死亡的肠道上皮细胞释放的可溶因子。哺乳动物体内caspase-3/7依赖性细胞凋亡之后释放的营养物质可促进多种肠杆菌科的生长。研究人员还识别出细菌定植的关键驱动因子。该结果为理解复杂的宿主-病原体互作关系及死亡诱导的营养释放作用提供了新角度。

https://www.nature.com/articles/s41586-021-03785-9

https://www.linkresearcher.com/t ... e-a11e-8a3b1ee8259f

Nature：揭秘肠道细菌利用死亡细胞所释放的营养物质作为燃料来引发宿主机体感染的分子机制
肠道感染
细菌定植
营养物质
小鼠
疗法
来源：本站原创 2021-08-09 09:04

http://news.bioon.com/article/6789689.html



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