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不生癌(一生中从不生癌、终生不生癌,并包括临床治癒后不复发) 主要参考文献:
(各种癌症的预防和治疗等、约10年前已经基本解决了。)
1.Nature:重磅!新型抗癌药物或能让癌细胞处于永久休眠状态!
http://news.bioon.com/article/6725571.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95262
组蛋白乙酰基转移酶KAT6A / B抑制剂诱导衰老并阻止肿瘤生长
Jonathan B. Baell, David J. Leaver, Stefan J. Hermans, et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature (2018), DOI: 10.1038/s41586-018-0387-5
https://www.nature.com/articles/s41586-018-0387-5
2.Science:重大突破!揭示γδ T细胞检测癌症和感染新机制
http://news.bioon.com/article/6749093.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
Sci:γδ T细胞检测癌症和感染 感应磷酸抗原 根除患病细胞
Marc Rigau et al. Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells. Science, 2020, doi:10.1126/science.aay5516.
https://science.sciencemag.org/c ... /08/science.aay5516
3.Nature:脑瘤恶化伴随神经网络的重塑
http://news.bioon.com/article/6749777.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
PIK3CA变体在神经胶质瘤形成过程中选择性启动脑活动亢进
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
https://www.nature.com/articles/s41586-020-1952-2
4.Nature:科学家鉴别出引发儿童肾脏癌症的新型机制
http://news.bioon.com/article/6748696.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
染色质读取器中的功能获得突变导致细胞命运受损
Wan, L., Chong, S., Xuan, F. et al. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature 577, 121–126 (2020) doi:10.1038/s41586-019-1842-7
https://www.nature.com/articles/s41586-019-1842-7
5.《科学》:儿童肾癌始于胚胎时期
http://paper.sciencenet.cn/htmlp ... 12501383454010.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
肾母细胞瘤的胚胎前体
Embryonal precursors of Wilms tumor
Tim H. H. Coorens1, Taryn D. Treger1,2,3, Reem Al-Saadi4,5, Luiza Moore1,2, Maxine G. B. Tran6,7, Thomas J. Mitchell1,2,8, Suzanne Tugnait4, Christine Thevanesan4, Matthew D. Young1, Thomas R. W. Oliver1,2,9, Minou Oostveen4,5, Grace Collord1,2,3, Patrick S. Tarpey2, Alex Cagan1, Yvette Hooks1, Mark Brougham10, Ben C. Reynolds11, Giuseppe Barone5, John Anderson4,5, Mette Jorgensen5, G. A. Amos Burke2,3, Johannes Visser2, James C. Nicholson2,3, Naima Smeulders5, Imran Mushtaq5, Grant D. Stewart2,8, Peter J. Campbell1, David C. Wedge12,13, Iñigo Martincorena1, Dyanne Rampling5, Liz Hook2,9, Anne Y. Warren2,9, Nicholas Coleman2,9, Tanzina Chowdhury5, Neil Sebire4,5, Jarno Drost14, Kourosh Saeb-Parsy2,8, Michael R. Stratton1, Karin Straathof4,5, Kathy Pritchard-Jones4,5, Sam Behjati1,2,3,*
Science 06 Dec 2019: Vol. 366, Issue 6470, pp. 1247-1251
https://science.sciencemag.org/content/366/6470/1247
6.Nature:诊断乳腺癌 人工智能完胜人类专家!
http://news.bioon.com/article/6748708.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
乳腺癌筛查AI系统的国际评估
McKinney, S.M., Sieniek, M., Godbole, V. et al. International evaluation of an AI system for breast cancer screening. Nature 577, 89–94 (2020) doi:10.1038/s41586-019-1799-6
https://www.nature.com/articles/s41586-019-1799-6
7.Nature:揭示摄入更多乳酸的黑色素瘤细胞是转移高手
http://news.bioon.com/article/6748361.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
代谢异质性赋予黑色素瘤转移潜能差异
Alpaslan Tasdogan et al. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature, 2019, doi:10.1038/s41586-019-1847-2.
https://www.nature.com/articles/s41586-019-1847-2
8.Cell:染色体外非编码DNA促进神经胶质瘤发生
http://news.bioon.com/article/6747050.html
http://www.kaseisyoji.com/forum. ... id=95264&page=1
功能增强子塑造染色体外致癌基因扩增
Cell Volume 179, Issue 6, 27 November 2019, Pages 1330-1341.e13
Article Functional Enhancers Shape Extrachromosomal Oncogene Amplifications
https://www.sciencedirect.com/sc ... 19312164?via%3Dihub
9.Nature:重磅!科学家成功揭示肿瘤中环状染色体外DNA的结构与功能
http://news.bioon.com/article/6747044.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D3
环状ecDNA促进染色质的可及性和高癌基因表达
Wu, S., Turner, K.M., Nguyen, N. et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature (2019) doi:10.1038/s41586-019-1763-5
https://www.nature.com/articles/s41586-019-1763-5
染色体外致癌基因扩增驱动肿瘤进化和遗传异质性
Turner, K., Deshpande, V., Beyter, D. et al. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature 543, 122–125 (2017) doi:10.1038/nature21356
https://www.nature.com/articles/nature21356
10.Nature等:揭示促进癌症扩散的生存技能!
http://news.bioon.com/article/6745675.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D5
E-钙黏着蛋白是乳腺癌多种模型转移所必需的
Veena Padmanaban, Ilona Krol, Yasir Suhail, et al. E-cadherin is required for metastasis in multiple models of breast cancer, Nature (2019) doi:10.1038/s41586-019-1526-3
https://www.nature.com/articles/s41586-019-1526-3
11.Nature:重磅!揭示癌症中RNA改变的分子特征!
http://news.bioon.com/article/6750096.html
http://www.kaseisyoji.com/forum. ... id=80396&extra=
癌症中RNA改变的基因组基础
Calabrese, C., Davidson, N.R., Demircioğlu, D. et al. Genomic basis for RNA alterations in cancer. Nature 578, 129–136 (2020). doi:10.1038/s41586-020-1970-0
https://www.nature.com/articles/s41586-020-1970-0
12.Nature:首个系统性癌症基因组图谱问世——揭示癌细胞演化之谜
http://news.bioon.com/article/6750110.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95281
2,658种癌症的进化史
The evolutionary history of 2,658 cancers, Nature (2020). DOI: 10.1038/s41586-019-1907-7 ,
https://www.nature.com/articles/s41586-019-1907-7
13.Cancer:植物来源药物可用于治疗头颈癌
http://news.bioon.com/article/6750171.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95285
APG-157在口腔癌中的随机1期安慰剂对照试验表明,该药具有系统吸收作用,并对细胞因子和肿瘤相关微生物具有抑制作用
Saroj K. Basak et al, A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated microbes, Cancer (2020). DOI: 10.1002/cncr.32644
https://www.ncbi.nlm.nih.gov/pubmed/32022261
14.Science:细胞间通讯如何导致白血病发生?
http://news.bioon.com/article/6750158.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95286
科学家发现细胞之间的流氓通信如何导致白血病
Scientists discover how rogue communications between cells lead to leukemia
https://medicalxpress.com/news/2 ... cells-leukemia.html
15.Nature:重大进展!新研究揭示最常见的SF3B1基因突变如何导致癌症
http://news.bioon.com/article/6745227.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D5
非典型BAF复合体的剪接破坏
Daichi Inoue et al. Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature, 2019, doi:10.1038/s41586-019-1646-9.
https://www.nature.com/articles/s41586-019-1646-9
16.《细胞》:中国学者国际上率先揭示肝癌分子特征全景和个性化诊治新策略
https://www.thepaper.cn/newsDetail_forward_4629110
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
https://www.cell.com/cell/fullte ... 37%3Fshowall%3Dtrue
17.Nature:真菌感染与胰腺癌发生之间的关系
http://news.bioon.com/article/6744684.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
真菌菌群通过激活MBL促进胰腺癌发生
Berk Aykut, Smruti Pushalkar, Ruonan Chen, Qianhao Li, Raquel Abengozar, Jacqueline I. Kim, Sorin A. Shadaloey, Dongling Wu, Pamela Preiss, Narendra Verma, Yuqi Guo, Anjana Saxena, Mridula Vardhan, Brian Diskin, Wei Wang, Joshua Leinwand, Emma Kurz, Juan A. Kochen Rossi, Mautin Hundeyin, Constantinos Zambrinis, Xin Li, Deepak Saxena, George Miller. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature, 2019; DOI: 10.1038/s41586-019-1608-2
https://www.nature.com/articles/s41586-019-1608-2
18.自然-化学:大肠杆菌素致癌机制获破解
http://paper.sciencenet.cn/htmlp ... 61455554152675.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
大环大肠菌素通过铜介导的氧化裂解诱导DNA双链断裂
https://www.nature.com/articles/s41557-019-0317-7
19.Science重大进展:科学家们发现肿瘤形成的原子驱动力
http://news.bioon.com/article/6742449.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
Mengzhao Xue et al. Structure elucidation of colibactin and its DNA cross-links, Science (2019). DOI: 10.1126/science.aax2685
http://science.sciencemag.org/lookup/doi/10.1126/science.aax2685
20.Nature:重磅!癌症新伎俩!癌细胞产生更多的Win,并让邻近的健康细胞产生更多的Lose,促进癌症生长
http://news.bioon.com/article/6741757.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
花同工型促进癌症的竞争性增长
Esha Madan et al. Flower isoforms promote competitive growth in cancer. Nature, 2019, doi:10.1038/s41586-019-1429-3.
https://www.nature.com/articles/s41586-019-1429-3
21.Nature:蛋白过度表达可能是癌细胞的致命弱点
http://news.bioon.com/article/6741706.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
Hung-Ji Tsai et al. Hypo-osmotic-like stress underlies general cellular defects of aneuploidy, Nature (2019). DOI: 10.1038/s41586-019-1187-2
https://www.nature.com/articles/s41586-019-1187-2
22.Science:打破传统!癌症基因组中的突变“热点”不一定会推动癌症的生长!
http://news.bioon.com/article/6740678.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Michael S. Lawrence et al. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science (2019). DOI: 10.1126/science.aaw2872
https://science.sciencemag.org/content/364/6447/eaaw2872
23.Nature:科学家有望实现让疲惫不堪的免疫细胞重新焕发活力 再次高效抑制癌症进展
http://news.bioon.com/article/6740600.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Omar Khan, Josephine R. Giles, Sierra McDonald, et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion, Nature (2019). DOI:10.1038/s41586-019-1325-x
https://www.nature.com/articles/s41586-019-1325-x
24.Science:重大突破!以前仅作为一种疾病生物标志物,如今发现CA19-9导致胰腺炎和胰腺癌产生
http://news.bioon.com/article/6740364.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
D.D. Engle el al.The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Science, 2019, doi:10.1126/science.aaw3145.
https://science.sciencemag.org/content/364/6446/1156
C.J. Halbrook el al. Hiding in plain sight. Science, 2019, doi:10.1126/science.aax9341.
https://science.sciencemag.org/content/364/6446/1132
25.Nature:挑战常规!FOXA1以三种不同方式化身为癌基因,促进癌症产生
http://news.bioon.com/article/6740393.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Abhijit Parolia et al. Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Nature, 2019, doi:10.1038/s41586-019-1347-4.
https://www.nature.com/articles/s41586-019-1347-4
26.Nature:中国科学家揭示尿苷二磷酸葡萄糖抑制肺癌转移 糖醛酸代谢中间物
http://news.bioon.com/article/6740376.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Xiongjun Wang et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature, 2019, doi:10.1038/s41586-019-1340-y.
https://www.nature.com/articles/s41586-019-1340-y
27.《自然》:科学家揭示乳腺癌细胞转移机制 有望为预防癌症复发提供新法
http://paper.sciencenet.cn/htmlp ... 10305854552422.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
E-cadherin is required for metastasis in multiple models of breast cancer
https://www.nature.com/articles/s41586-019-1526-3
28.Nat Commun:揭示癌细胞转移的最佳路径
http://news.bioon.com/article/6744136.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
Matthew R. Zanotelli et al. Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Nature Communications (2019). DOI: 10.1038/s41467-019-12155-z
https://www.nature.com/articles/s41467-019-12155-z
29.Science:发现五种基因能让健康细胞癌变
抑癌53RB损,肺前膀小细胞基表似
http://news.bioon.com/article/6728438.html
http://www.kaseisyoji.com/forum. ... id=80527&extra=
30.Nature:重磅!科学家成功解析出转移性乳腺癌的基因组特性!
http://news.bioon.com/article/6739034.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D12
Francois Bertucci, Charlotte K. Y. Ng, Anne Patsouris, et al,. Genomic characterization of metastatic breast cancers, Nature 569, 560–564 (2019) doi:10.1038/s41586-019-1056-z
https://www.nature.com/articles/s41586-019-1056-z
31.Cell:新研究揭示抗感染与抗癌症的新机制
http://news.bioon.com/article/6738965.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Weina Zhang et al, Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS, Cell (2019). DOI: 10.1016/j.cell.2019.05.003
https://www.sciencedirect.com/sc ... 1930501X?via%3Dihub
32.Nature:来自中枢神经系统的神经祖细胞促进癌症中的神经发生
http://news.bioon.com/article/6738819.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Philippe Mauffrey et al. Progenitors from the central nervous system drive neurogenesis in cancer. Nature, 2019, doi:10.1038/s41586-019-1219-y.
https://www.nature.com/articles/s41586-019-1219-y
33.Nature:科学家锁定癌症相关蛋白质,有望延缓癌症进展
http://ctxy.bioon.com/xy/article_pc.html?id=6738594
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Dmitry I. Gabrilovich et al. Fatty acid transporter 2 reprograms neutrophils in cancer, Nature (2019). DOI: 10.1038/s41586-019-1118-2
https://www.nature.com/articles/s41586-019-1118-2
34.Nature:糖皮质激素促进乳腺癌转移
http://news.bioon.com/article/6735356.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid94539
Milan M. S. Obradović et al. Glucocorticoids promote breast cancer metastasis. Nature, 2019, doi:10.1038/s41586-019-1019-4.
https://www.nature.com/articles/s41586-019-1019-4
35.Nature:科学家成功揭示癌症的代谢成瘾特性
http://news.bioon.com/article/6737526.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Sudhir Chowdhry, Ciro Zanca, Utkrisht Rajkumar, et al. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling, Nature (2019). DOI: 10.1038/s41586-019-1150-2
https://www.nature.com/articles/s41586-019-1150-2
36.欧洲癌症杂志:哪些生活习惯会致癌? 胖晒病毒宫口肛癌
http://ctxy.bioon.com/xy/article_pc.html?id=6721281
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
37.Cell:大规模乳腺癌细胞组成分析带来新型治疗方法
http://ctxy.bioon.com/xy/article_pc.html?id=6737368
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Johanna Wagner et al, A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer, Cell (2019). DOI: 10.1016/j.cell.2019.03.005
https://www.cell.com/cell/fullte ... 73%3Fshowall%3Dtrue
38.Cell:通过构建胰腺癌干细胞分子依赖性图谱,揭示胰腺癌治疗新策略
http://ctxy.bioon.com/xy/article_pc.html?id=6737185
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Nikki K. Lytle et al. A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell, 2019, doi:10.1016/j.cell.2019.03.010.
https://www.cell.com/cell/fullte ... 27%3Fshowall%3Dtrue
39.《自然》:面对癌症之王 中美科学家们联合找到了诊疗新思路
http://news.bioon.com/article/6737168.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
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