Nat:新冠病毒Delta突变株对抗体中和活性敏感降 疫苗差传播快

顾汉现

新冠病毒Delta突变株对抗体中和活性的敏感度降低  Delta传播快疫苗效差

无论是康复患者，还是疫苗接种者的血清，对抗Delta毒株的中和效力都低于抗Alpha病毒。免疫逃避。
在SARS-CoV的-2 B.1.617谱系(即Delta突变株)在2020年10月被确定在印度。此后，它在印度和英国的一些地区占据主导地位，并蔓延到许多其他国家。 该谱系包括三个主要亚型（B1.617.1、B.1.617.2 和 B.1.617.3），它们在 SARS-可能增加这些变体的免疫逃避潜力的 CoV-2 刺突蛋白。B.1.617.2（也称为 Delta 变体）被认为比其他变体传播得更快。Delta传播快疫苗效差。疫苗差传播快。

领研网

2021/08/22

论文
论文标题：Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
作者：Planas, Delphine, Veyer, David, Baidaliuk, Artem, Staropoli, Isabelle, Guivel-Benhassine, Florence, Rajah, Maaran Michael, Planchais, Cyril, Porrot, Françoise, Robillard, Nicolas, Puech, Julien, Prot, Matthieu, Gallais, Floriane, Gantner, Pierre, Velay, Aurélie, Le Guen, Julien, Kassis-Chikhani, Najiby, Edriss, Dhiaeddine, Belec, Laurent, Seve, Aymeric, Courtellemont, Laura, Péré, Hélène, Hocqueloux, Laurent, Fafi-Kremer, Samira, Prazuck, Thierry, Mouquet, Hugo, Bruel, Timothée, Simon-Lorière, Etienne, Rey, Felix A., Schwartz, Olivier

期刊：Nature
发表时间：2021/07/08
数字识别码：10.1038/s41586-021-03777-9
摘要：The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1,2,3,4,5. Since then, it has become dominant in some regions of India and in the UK, and has spread to many other countries6. The lineage includes three main subtypes (B1.617.1, B.1.617.2 and B.1.617.3), which contain diverse mutations in the N-terminal domain (NTD) and the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein that may increase the immune evasion potential of these variants. B.1.617.2—also termed the Delta variant—is believed to spread faster than other variants. Here we isolated an infectious strain of the Delta variant from an individual with COVID-19 who had returned to France from India. We examined the sensitivity of this strain to monoclonal antibodies and to antibodies present in sera from individuals who had recovered from COVID-19 (hereafter referred to as convalescent individuals) or who had received a COVID-19 vaccine, and then compared this strain with other strains of SARS-CoV-2. The Delta variant was resistant to neutralization by some anti-NTD and anti-RBD monoclonal antibodies, including bamlanivimab, and these antibodies showed impaired binding to the spike protein. Sera collected from convalescent individuals up to 12 months after the onset of symptoms were fourfold less potent against the Delta variant relative to the Alpha variant (B.1.1.7). Sera from individuals who had received one dose of the Pfizer or the AstraZeneca vaccine had a barely discernible inhibitory effect on the Delta variant. Administration of two doses of the vaccine generated a neutralizing response in 95% of individuals, with titres three- to fivefold lower against the Delta variant than against the Alpha variant. Thus, the spread of the Delta variant is associated with an escape from antibodies that target non-RBD and RBD epitopes of the spike protein.

所属学科：
免疫学
（导读 阿金）本研究分离出一位感染新冠病毒Delta突变株患者体内的病毒株，检测了该毒株对于单克隆抗体和数名康复患者及疫苗接种受试者血清样本中的抗体敏感性。Delta毒株对于一些抗N端结构域和抗受体结合域（RBD）单克隆抗体的中和活性表现出抗性。而且，无论是康复患者，还是疫苗接种者的血清，对抗Delta毒株的中和效力都低于抗Alpha病毒。因此，Delta突变株的传播与靶向刺突蛋白非RBD以及RBD表位抗体的免疫逃避相关。

https://www.nature.com/articles/s41586-021-03777-9

https://www.linkresearcher.com/t ... 1-a5ff-ca3657aee977



华成旅行社  欢迎来电咨询：

电话：03-3833-9823  / 03-5688-1863
FAX ：03-3833-9873  / 03-3834-5891

SOFTBANK电话：080-3416-2275   担当：小郭  微信号：08034162275
SOFTBANK电话：090-2172-4325   担当：小于  微信号：TYOSCL4325
SOFTBANK电话：080-3398-4387   担当：小李  微信号：huacheng4387
SOFTBANK电话：080-3523-4388   担当：小何  微信号：huacheng602
SOFTBANK电话：080-3084-4389   担当：小马  微信号：huacheng858

http://www.kaseisyoji.com/forum.php?mod=forumdisplay&fid=10