Nature：CNS巨噬细胞亚群的特化发生在特定生境中 先天免疫

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CNS巨噬细胞亚群的特化发生在特定生境中

领研网

2022/05/09

论文
论文标题：Specification of CNS macrophage subsets occurs postnatally in defined niches
作者：Takahiro Masuda, Lukas Amann, Marco Prinz, et al.
期刊：Nature
发表时间：2022/04/20
数字识别码：10.1038/s41586-022-04596-2
摘要：All tissue-resident macrophages of the central nervous system (CNS)—including parenchymal microglia, as well as CNS-associated macrophages (CAMs1) such as meningeal and perivascular macrophages2,3,4,5,6,7—are part of the CNS endogenous innate immune system that acts as the first line of defence during infections or trauma2,8,9,10. It has been suggested that microglia and all subsets of CAMs are derived from prenatal cellular sources in the yolk sac that were defined as early erythromyeloid progenitors11,12,13,14,15. However, the precise ontogenetic relationships, the underlying transcriptional programs and the molecular signals that drive the development of distinct CAM subsets in situ are poorly understood. Here we show, using fate-mapping systems, single-cell profiling and cell-specific mutants, that only meningeal macrophages and microglia share a common prenatal progenitor. By contrast, perivascular macrophages originate from perinatal meningeal macrophages only after birth in an integrin-dependent manner. The establishment of perivascular macrophages critically requires the presence of arterial vascular smooth muscle cells. Together, our data reveal a precisely timed process in distinct anatomical niches for the establishment of macrophage subsets in the CNS.

所属学科：
神经科学

（导读 阿金）中枢神经系统（CNS）中的所有组织驻留巨噬细胞都是CNS内源性先天免疫系统的一部分，是防御感染或创伤的首道防线。本研究使用细胞命运图谱系统、单细胞测序和细胞特异性突变，发现只有脑膜巨噬细胞和小胶质细胞共有同一个产前祖细胞。血管周围巨噬细胞仅在出生之后以整合素依赖方式分化自围产期脑膜巨噬细胞。最终数据揭示了在CNS中建立巨噬细胞亚群的独特解剖生境时间过程。

文章标签
中枢神经系统
组织驻留巨噬细胞
内源性先天免疫系统
细胞命运图谱
脑膜巨噬细胞
小胶质细胞

https://www.nature.com/articles/s41586-022-04596-2

https://www.linkresearcher.com/t ... 5-9a4b-dd292c5f831a



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