2022/09/20
论文
论文标题：Identification of trypsin-degrading commensals in the large intestine
作者：Youxian Li, Eiichiro Watanabe, Yusuke Kawashima, Damian R. Plichta, Zhujun Wang, Makoto Ujike, Qi Yan Ang, Runrun Wu, et al.
期刊：Nature
发表时间：2022/09/07
数字识别码：10.1038/s41586-022-05181-3
摘要：Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions1,2,3. However, the players and mechanisms that underlie protease regulation in the intestinal lumen have remained unclear. Here we show that Paraprevotella strains isolated from the faecal microbiome of healthy human donors are potent trypsin-degrading commensals. Mechanistically, Paraprevotella recruit trypsin to the bacterial surface through type IX secretion system-dependent polysaccharide-anchoring proteins to promote trypsin autolysis. Paraprevotella colonization protects IgA from trypsin degradation and enhances the effectiveness of oral vaccines against Citrobacter rodentium. Moreover, Paraprevotella colonization inhibits lethal infection with murine hepatitis virus-2, a mouse coronavirus that is dependent on trypsin and trypsin-like proteases for entry into host cells4,5. Consistently, carriage of putative genes involved in trypsin degradation in the gut microbiome was associated with reduced severity of diarrhoea in patients with SARS-CoV-2 infection. Thus, trypsin-degrading commensal colonization may contribute to the maintenance of intestinal homeostasis and protection from pathogen infection.
近日，日本RIKEN综合医学科学中心的Kenya Honda团队在Nature 上发表题为Identification of trypsin-degrading commensals in the large intestine 的文章。该文章鉴定出了肠道内降解胰蛋白酶的细菌种类，并探讨了细菌降解胰蛋白酶的机制以及对感染性疾病的影响。
