线粒体代谢决定了神经元发育的物种特异性节奏。与其他哺乳动物相比，人类大脑皮层的神经元发育时间大大延长。与小鼠相比，人皮层神经元的线粒体发育较慢，同时线粒体代谢活性较低，尤其是氧化磷酸化。小鼠比人、与氧化磷酸化等相关基因表达增加的时间点出现得更早。刺激人类神经元中的线粒体代谢导致体外和体内加速发育，导致细胞提前成熟。对线粒体活性药物处理、对线粒体活性进行操纵，促进神经元分化、显著促进提高神经元的成熟速度。本文是人类和哺乳动物大脑皮层神经元发育的关联基础科学研究论文。
(Baidu Translator: )
Science: Mitochondrial Metabolism and Species Specific Neuron Development: Rapid Metabolism and Development in Humans and Mammals
Mitochondrial metabolism determines the species specific rhythm of neuronal development. Compared with other mammals, the development time of neurons in the human cerebral cortex is significantly prolonged. Compared with mice, the development of mitochondria in human cortical neurons is slower and their metabolic activity is lower, especially oxidative phosphorylation. Mice appear earlier than humans, and the timing of increased gene expression related to oxidative phosphorylation occurs. Stimulating mitochondrial metabolism in human neurons leads to accelerated development in vitro and in vivo, leading to premature cell maturation. Treatment of mitochondrial active drugs and manipulation of mitochondrial activity can promote neuronal differentiation and significantly improve the maturation rate of neurons. This article is a basic scientific research paper on the correlation between the development of cortical neurons in human and mammalian brains.
（百度翻訳： ）
Science：ミトコンドリア代謝と種特異的ニューロン発育ヒト、哺乳動物の代謝が速く発育が速い
ミトコンドリア代謝はニューロン発育の種特異的リズムを決定する。他の哺乳動物と比べて、ヒト大脳皮質のニューロン発育時間は大幅に延長された。マウスと比べて、ヒト皮質ニューロンのミトコンドリア発育は遅く、同時にミトコンドリア代謝活性は低く、特に酸化リン酸化である。マウスはヒト、リン酸化物の酸性化などに関連する遺伝子発現が増加した時点よりも早く出現した。ヒトニューロン中のミトコンドリア代謝を刺激することは体外と体内の発育を加速させ、細胞の早期成熟をもたらす。ミトコンドリア活性薬物の処理、ミトコンドリア活性の操作、ニューロン分化の促進、ニューロンの成熟速度の向上の顕著な促進。本文は人類と哺乳動物の大脳皮質ニューロン発育の関連基礎科学研究論文である。
BioArt
2023/02/07
论文
论文标题：Mitochondria metabolism sets the species-specific tempo of neuronal development
作者：Ryohei Iwata, Pierre Casimir, Emir Erkol, Leïla Boubakar, Mélanie Planque, Isabel M. Gallego López, Martyna Ditkowska, Vaiva Gaspariunaite, Sofie Beckers, Daan Remans, Katlijn Vints, Anke Vandekeere, Suresh Poovathingal, Matthew Bird, Ine Vlaeminck, Eline Creemers, Keimpe Wierda, Nikky Corthout, Pieter Vermeersch, Sébastien Carpentier, Kristofer Davie, Massimiliano Mazzone, Natalia V. Gounko, Stein Aerts, Bart Ghesquière, Sarah-Maria Fendt, Pierre Vanderhaeghen
期刊：Science
发表时间：2023/01/26
数字识别码：10.1126/science.abn4705
摘要：Neuronal development in the human cerebral cortex is considerably prolonged compared to that of other mammals. We explored whether mitochondria influence the species-specific timing of cortical neuron maturation. By comparing human and mouse cortical neuronal maturation at high temporal and cell resolution, we found a slower mitochondria development in human cortical neurons compared with that in the mouse, together with lower mitochondria metabolic activity, particularly that of oxidative phosphorylation. Stimulation of mitochondria metabolism in human neurons resulted in accelerated development in vitro and in vivo, leading to maturation of cells weeks ahead of time, whereas its inhibition in mouse neurons led to decreased rates of maturation. Mitochondria are thus important regulators of the pace of neuronal development underlying human-specific brain neoteny.
所属学科：
神经科学
生物
撰文丨十一月
人类大脑皮层神经元的发育时间与其他哺乳动物相比要长的多。这一发育以及成熟过程的延长可能正是人脑功能增强的基础【1】。线粒体代谢过程是否影响到不同物种中皮层神经元的成熟呢？为了揭开这一问题的答案，比利时鲁汶大学Pierre Vanderhaeghen 在Science发文题为Mitochondria metabolism sets the species-specific tempo of neuronal development，通过对人类和小鼠皮层神经元高时间和细胞分辨率下的比较，发现人类皮层神经元中线粒体发育较慢、代谢活性较低，刺激人类神经元中线粒体代谢可以加速神经元的发育，为理解线粒体代谢与不同物种神经元成熟过程提供了新的见解。
1. B. Libé-Philippot, P. Vanderhaeghen, Cellular and molecular mechanisms linking human cortical development and evolution. Annu. Rev. Genet.55, 555–581 (2021).
2. M. Knobloch, S. Jessberger, Metabolism and neurogenesis. Curr. Opin. Neurobiol.42, 45–52 (2017).
3. M. J. Bird, I. Adant, P. Windmolders, I. Vander Elst, C. Felgueira, R. Altassan, S. C. Gruenert, B. Ghesquière, P. Witters, D. Cassiman, P. Vermeersch, Oxygraphy versus enzymology for the biochemical diagnosis of primary mitochondrial disease. Metabolites9, 220 (2019).
