论文
论文标题：Functional T cells are capable of supernumerary cell division and longevity
作者：Soerens, Andrew G., Künzli, Marco, Quarnstrom, Clare F., Scott, Milcah C., Swanson, Lee, Locquiao, JJ., Ghoneim, Hazem E., Zehn, Dietmar, Youngblood, Benjamin, Vezys, Vaiva, Masopust, David
期刊：Nature
发表时间：2023/01/18
数字识别码：10.1038/s41586-022-05626-9
摘要：Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans1,2,3. To provide immunity, transiently stimulated CD8+ T cells undergo unusually rapid bursts of numerous cell divisions, and then form quiescent long-lived memory cells that remain poised to reproliferate following subsequent immunological challenges. Here we addressed whether T cells are intrinsically constrained by chronological or cell-division limits. We activated mouse T cells in vivo using acute heterologous prime–boost–boost vaccinations4, transferred expanded cells to new mice, and then repeated this process iteratively. Over 10 years (greatly exceeding the mouse lifespan)5 and 51 successive immunizations, T cells remained competent to respond to vaccination. Cells required sufficient rest between stimulation events. Despite demonstrating the potential to expand the starting population at least 1040-fold, cells did not show loss of proliferation control and results were not due to contamination with young cells. Persistent stimulation by chronic infections or cancer can cause T cell proliferative senescence, functional exhaustion and death6. We found that although iterative acute stimulations also induced sustained expression and epigenetic remodelling of common exhaustion markers (including PD1, which is also known as PDCD1, and TOX) in the cells, they could still proliferate, execute antimicrobial functions and form quiescent memory cells. These observations provide a model to better understand memory cell differentiation, exhaustion, cancer and ageing, and show that functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan.
近日，来自美国明尼苏达大学的David Masopus研究团队在Nature上发表题为Functional T cells are capable of supernumerary cell division and longevity的文章，他们通过三次异质性免疫接种策略在小鼠体内激活T细胞，并移植到新个体中，然后迭代重复该过程，在超过10年的时间里，连续51次的免疫接种，T细胞仍然具有响应免疫刺激的能力，并且在增殖过程中细胞并不会失去控制转变成癌细胞。
