异质小鼠种群中长寿的性别和年龄依赖遗传学。在酵母、线虫、果蝇、小鼠等模型生物中发现了2000多个与长寿相关的基因。多基因遗传。本文是长寿关联基础医学研究论文。
(Google Translate: )
Searching for "longevity genes", "Science" research breakthroughs Gender age polygenic
Sex- and age-dependent genetics of longevity in heterogeneous mouse populations. More than 2,000 longevity-related genes have been found in model organisms such as yeast, nematodes, Drosophila, and mice. polygenic inheritance. This article is a research paper on longevity-associated basic medicine.
（グーグル翻訳： ）
「長寿遺伝子」を探る、「科学」研究のブレークスルー 性別・年齢・多遺伝子性
異種マウス集団における寿命の性別および年齢依存性遺伝学。 酵母、線虫、ショウジョウバエ、マウスなどのモデル生物では、2,000 以上の寿命関連遺伝子が発見されています。 多遺伝子遺伝。 この記事は、長寿に関連する基礎医学に関する研究論文です。
学术经纬
2022/11/02
论文
论文标题：Sex- and age-dependent genetics of longevity in a heterogeneous mouse population
作者：Maroun Bou Sleiman, Suheeta Roy, Arwen W. Gao, Marie C. Sadler, Giacomo V. G. von Alvensleben, Hao Li, Saunak Sen, David E. Harrison, James F. Nelson, Randy Strong, Richard A. Miller, Zoltán Kutalik, Robert W. Williams, Johan Auwerx
期刊：Science
发表时间：2022/09/30
数字识别码：10.1126/science.abo3191
摘要：DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chromosome 12 and identified sex-specific QTLs, some of which we detected only in older mice. Similar relations between life history and longevity were uncovered in mice and humans, underscoring the importance of early access to nutrients and early growth. We identified common age- and sex-specific genetic effects on gene expression that we integrated with model organism and human data to create a hypothesis-building interactive resource of prioritized longevity and body weight genes. Finally, we validated Hipk1, Ddost, Hspg2, Fgd6, and Pdk1 as conserved longevity genes using Caenorhabditis elegans life-span experiments.
为了突破这一局限，此次的新研究引人注目地对3200多只小鼠进行了基因分型。“在识别寿命基因的同类研究中，是小鼠数量最多的一项研究。”作者之一James F. Nelson博士指出。不仅数量多，更重要的是，这些小鼠有非常多样化的遗传背景。不同品系的小鼠在同一个基因位点可能有不同的变异版本，导致产生的蛋白略有不同。而随着年龄的增长，即便是细微的差别也可能导致不同的健康结果。这种多样性“模拟了人类群体的遗传多样性”。
参考资料：
[1] Maroun Bou Sleiman et al., (2022) Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Science. Doi: 10.1126/science.abo3191
[2] The genetics of a long life. Science Doi: 10.1126/science.ade3119
[3] Clusters of genes help mice live longer, team reports. Retrieved Oct. 17, 2022 from https://news.uthscsa.edu/cluster ... onger-team-reports/
