感知身体的内部状态是一个重要的生命保障过程，它可以维持生理平衡，提供动力驱动并塑造我们的思想和情绪。作为内部感受的关键体脑轴，结节和颈静脉神经节中的 迷走神经VSN 将来自呼吸系统、心血管系统、胃肠道、内分泌系统和免疫系统的内脏器官的大量信号传递到脑干。通过 迷走神经VSN 传达的信号在大脑中被精确区分，以产生高度特异性的反应。本文是肺、心、胃肠道、内分泌系统、免疫系统等内脏信号感知传递神经关联的基础医学研究论文。
(Baidu EnglishTranslation: )
Nature: multidimensional coding architecture of vagal sensory system
Perceiving the internal state of the body is an important life support process. It can maintain physiological balance, provide power drive and shape our thoughts and emotions. As the key body axis of internal perception, the vagus nerve VSN in the nodule and jugular ganglion transmits a large number of signals from the internal organs of the respiratory system, cardiovascular system, gastrointestinal tract, endocrine system and immune system to the brain stem. The signals transmitted through the vagal VSN are accurately distinguished in the brain to produce a highly specific response. This paper is a basic medical research paper on the neural correlation of visceral signal perception and transmission, such as lung, heart, gastrointestinal tract, endocrine system and immune system.
(バイドゥ日本語訳: )
Nature:迷走神経内感受システムの多次元符号化アーキテクチャ
体の内部状態を感知することは重要な生命保障過程であり、生理的なバランスを維持し、動力駆動を提供し、私たちの思想と情緒を形作ることができる。内部感受性の重要な脳軸として、結節と頸静脈神経節における迷走神経VSNは、呼吸系、心血管系、胃腸管、内分泌系、免疫系の内臓器官からの大量の信号を脳幹に伝達する。迷走神経VSNによって伝達される信号は脳で正確に区別され、高度に特異的な反応を生じる。本文は肺、心、胃腸道、内分泌系、免疫系などの内臓信号感知伝達神経関連の基礎医学研究論文である。
领研网
2022/04/11
论文
论文标题：A multidimensional coding architecture of the vagal interoceptive system
作者：Qiancheng Zhao, Chuyue D. Yu, Rui Wang, Qian J. Xu, Rafael Dai Pra, Le Zhang & Rui B. Chang
期刊：Nature
发表时间：2022/03/16
数字识别码：10.1038/s41586-022-04515-5
摘要：Interoception, the ability to timely and precisely sense changes inside the body, is critical for survival1,2,3,4. Vagal sensory neurons (VSNs) form an important body-to-brain connection, navigating visceral organs along the rostral–caudal axis of the body and crossing the surface–lumen axis of organs into appropriate tissue layers5,6. The brain can discriminate numerous body signals through VSNs, but the underlying coding strategy remains poorly understood. Here we show that VSNs code visceral organ, tissue layer and stimulus modality—three key features of an interoceptive signal—in different dimensions. Large-scale single-cell profiling of VSNs from seven major organs in mice using multiplexed projection barcodes reveals a ‘visceral organ’ dimension composed of differentially expressed gene modules that code organs along the body’s rostral–caudal axis. We discover another ‘tissue layer’ dimension with gene modules that code the locations of VSN endings along the surface–lumen axis of organs. Using calcium-imaging-guided spatial transcriptomics, we show that VSNs are organized into functional units to sense similar stimuli across organs and tissue layers; this constitutes a third ‘stimulus modality’ dimension. The three independent feature-coding dimensions together specify many parallel VSN pathways in a combinatorial manner and facilitate the complex projection of VSNs in the brainstem. Our study highlights a multidimensional coding architecture of the mammalian vagal interoceptive system for effective signal communication.
