论文
论文标题：Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice
作者：Emi Hasegawa, Ai Miyasaka, Katsuyasu Sakurai, Yoan Cherasse, Yulong Li, Takeshi Sakurai
期刊：Science
发表时间：2022/03/04
数字识别码：10.1126/science.abl6618
摘要：The sleep cycle is characterized by alternating non–rapid eye movement (NREM) and rapid eye movement (REM) sleeps. The mechanisms by which this cycle is generated are incompletely understood. We found that a transient increase of dopamine (DA) in the basolateral amygdala (BLA) during NREM sleep terminates NREM sleep and initiates REM sleep. DA acts on dopamine receptor D2 (Drd2)–expressing neurons in the BLA to induce the NREM-to-REM transition. This mechanism also plays a role in cataplectic attacks—a pathological intrusion of REM sleep into wakefulness—in narcoleptics. These results show a critical role of DA signaling in the BLA in initiating REM sleep and provide a neuronal basis for sleep cycle generation.
参考资料：
[1] Emi Hasegawa et al., (2022) Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science. Doi: 10.1126/science.abl6618
[2] Elda Arrigoni & Patrick M. Fuller (2022) Addicted to dreaming. Science. Doi: 10.1126/science.abo1987
