哺乳动物的癌症风险。什么动物容易生癌:食肉动物多于食草动物 。高脂肪、低纤维的饮食，低运动量，年纪越大、细胞积累的突变越多、越易致癌症。适素多荤少。本文是动物学、癌症学基础科学研究论文。
(Baidu translation: )
Nature: what animals are not prone to cancer? Scientists examined nearly 200 species to see what they found
Cancer risk in mammals. What animals are prone to cancer: more carnivores than herbivores. High fat, low fiber diet, low exercise, the older, the more cell mutations accumulated, the more likely to cause cancer. More vegetables and less meat. This paper is a basic scientific research paper of zoology and oncology.
（百度翻訳： ）
『自然』：どんな動物が癌になりにくいですか？科学者は200近くの種を検査して、彼らが何を発見したかを見てみました。
哺乳動物の癌リスク。どんな動物が癌になりやすいか：食肉動物は草食動物より多い。高脂肪、低繊維の食事、低運動量、年を取るほど、細胞蓄積の突然変異が多くなり、癌になりやすい。適素多肉少。本文は動物学、癌学基礎科学研究論文である。
学术经纬
2021/12/28
论文
论文标题：Cancer risk across mammals
作者：Vincze, Orsolya, Colchero, Fernando, Lemaître, Jean-Francois, Conde, Dalia A., Pavard, Samuel, Bieuville, Margaux, Urrutia, Araxi O., Ujvari, Beata, Boddy, Amy M., Maley, Carlo C., Thomas, Frédéric, Giraudeau, Mathieu
期刊：Nature
发表时间：2021/12/22
数字识别码：10.1038/s41586-021-04224-5
摘要：Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations1,2. While elevated cancer risk with larger body size and/or longevity has been documented within species3,4,5, Peto’s paradox indicates the apparent lack of such an association among taxa6. Yet, unequivocal empirical evidence for Peto’s paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto’s paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.
