多巴胺促进内嗅皮层的联想记忆编码。动物脑纹状体神经递质多巴胺奖励强化学习。奖学。本文为记忆能力关联的心理生理学基础研究论文。
(Baidu Translator: )
Nature: Explore the century-old mystery of memory. Why do some smells always remind people of the past striatal dopamine
Dopamine promotes associative memory coding in the entorhinal cortex. The neurotransmitter dopamine in the striatum of animal brain rewards reinforcement learning. Scholarship. This paper is a basic research paper on psychophysiology related to memory ability.
（百度翻訳： ）
Nature：記憶の百年の謎を探ると、なぜか過去の紋状体ドーパミンを思い出す匂いがする
ドーパミンは内嗅皮質の連想記憶コードを促進する。動物脳紋様体神経伝達質ドーパミンは強化学習を奨励する。賞学。本文は記憶能力関連の心理生理学基礎研究論文である。
期刊：Nature
发表时间：2021/09/22
数字识别码：10.1038/s41586-021-03948-8
摘要：Mounting evidence shows that dopamine in the striatum is critically involved in reward-based reinforcement learning1,2. However, it remains unclear how dopamine reward signals influence the entorhinal–hippocampal circuit, another brain network that is crucial for learning and memory3,4,5. Here, using cell-type-specific electrophysiological recording6, we show that dopamine signals from the ventral tegmental area and substantia nigra control the encoding of cue–reward association rules in layer 2a fan cells of the lateral entorhinal cortex (LEC). When mice learned novel olfactory cue–reward associations using a pre-learned association rule, spike representations of LEC fan cells grouped newly learned rewarded cues with a pre-learned rewarded cue, but separated them from a pre-learned unrewarded cue. Optogenetic inhibition of fan cells impaired the learning of new associations while sparing the retrieval of pre-learned memory. Using fibre photometry, we found that dopamine sends novelty-induced reward expectation signals to the LEC. Inhibition of LEC dopamine signals disrupted the associative encoding of fan cells and impaired learning performance. These results suggest that LEC fan cells represent a cognitive map of abstract task rules, and that LEC dopamine facilitates the incorporation of new memories into this map.
