【Abstract】 Experiment 1 : Preattentive processing of musical features in major depressive disorderObjective:By using the event-related potentials,the present study aims to explore preattentive processing of musical features in patients with major depressive disorder.Methods:MMN responses to different musical features were compared in 20 patients with MDD and 20 age-matched healthy controls.The multi-feature paradigm was used to examine automatic change detection of six different musical sound features(pitch,timbre,location,intensity,slide,rhythm)in a complex musical context.Severity of depression and co-morbid anxiety were evaluated using the Hamilton Rating Scale of Depression(HRSD-17)and the Hamilton Anxiety Rating Scale(HAMA).Results:1.MMNs were obtained with all deviants.2.The amplitudes of timbre-MMN were significantly larger in MDD patients than in healthy controls(F = 7.105,p = 0.011),while the other deviants(pitch,location,intensity,slide and rhythm)elicited similar MMN across groups.3.For MDD patients,the amplitudes and latencies of MMNs did not correlate with severity of depression or co-morbid anxiety.Conclusion : Patients with MDD do not perform at the same level as controls in automatic change detection of timbre.This dysfunction is considered to be a trait-dependent feature of MDD.Experiment 2 :
Preattentive processing of emotional music informationObjective:This study was to investigate the preattentive processing of emotional music information and validate the paradigm used.Methods:20 healthy and untrained volunteers were recruited for this study.Stimuli included 24 emotional music excerpts which have been estimated previously as happy music and sad music.Reverse-oddball paradigm was used.Subjects were instructed to watch a silent movie but to ignore the musical stimuli delivered through the headphone.The mean amplitudes of the ERPs elicited by emotional music excerpts as standard or deviant stimuli was analyzed.Results:There was a significant main effect of Type(F(1,19)= 33.680,p<0.001)in amplitudes of the ERPs elicited by happy music,suggesting happy-MMN was obtained;the sad-MMN was not obtained as there was no significant main effect of Type(F(1,19)= 2.261,p = 0.149).Conclusion:This paradigm can elicit happy-MMN while the sad-MMN was not obtained.Experiment 3 : Preattentive processing of emotional music information in major depressive disorderObjective:The current study aims to investigate preattentive processing of emotional music information in patients with major depressive disorder.Methods:20 patients with major depressive disorder and 20 age/gender-matched healthy controls were recruited for this study.Stimuli included 24 emotional music excerpts which have been estimated previously as happy music and sad music.Reverse-oddball paradigm was used.Subjects were instructed to watch a silent movie but to ignore the musical stimuli delivered through the headphone.The mean amplitudes of the MMN elicited by emotional music excerpts was analyzed.Results:1.Happy or sad music deviants did not evoked MMN in patients with MDD;.2.There was a significant main effect of Group in amplitudes of happy-MMN ( F =6.834,p<0.05),deriving from the MMN in MDD decreased significantly.Conclusion:There was dysfunction in preattentive processing of sad music in major depressive disorder.Experiment 4 : Quantitative electroencephalogram of music in patients with major depressive disorderObjective:By using the quantitative electroencephalogram,the present study was to investigate the power of each rhythm band of electroencephalogram in patients with depression under music background.Methods:20 MDD patients and 20 age/gender-matched healthy controls were recruited in this study.EEG were recorded in a resting awake condition with the eyes open and with music delivered through headphone for 9 minutes,respectively.EEG signals were processed offline with the method of Short time Fourier transform(STFT).We select electrodes F3、FZ、F4、C3、CZ、C4、P3、PZ、P4、01、OZ、O2 to calculate the power for 4 thythm bands:δ(1-3.5 Hz),0(4-7 Hz),a(8-13 Hz),β(13-30 Hz);we also select FP1、FP2、F7、F8 to calculate FAA metric which reflects the frontal alpha assymetry.Results:1.Under resting condition,the main effect of Group in β band was significant(F＝8.803,p= 0.005).Under music condition,the main effect of Group in δ band was significant(F(1,38)= 9.888,P=0.003).2.In patients with MDD,the main effects of Condition in a and β band were significant(a:F = 26.555,p<0.001;β:F = 22.052,p<0.001),deriving from power ofα and β band were significantly lower in music condition than resting condition.In patients with MDD and healthy controls,the main effect of Condition in 8 band was marginally significant(MDD:F = 4.334,p= 0.051;HC:F = 3.139,p = 0.092);the main effect of Condition in 0 band was significant(MDD:F = 9.977,p = 0.005;HC:F ＝7.517,p = 0.013). 3 . Under resting condition,the main effect of Group in FAA metric was marginally significant(F = 3.024,p = 0.090). 4 . The power in all of the four bands and FAA metric were not correlated with the scores on HRSD-17 or HAMA in patients with MDD.Conclusion:1.Music modulates power of a and β band in patients with major depressive disorder.2.Patients with MDD exhibited dysfunctions in brain acitivity,including increased power in β band under resting condition and decreased power in δ band under music condition.In addition,there was a trend of frontal alpha asymmetry in MDD patients. 还原
【关键词】 抑郁障碍； 音乐； 前注意加工； 失匹配负波； 定量脑电图；
【Key words】 Major depressive disorder； Music； Preattentive processing； Mismatch negativity； Quantitative electroencephalogram；
【网络出版投稿人】 大连医科大学【网络出版年期】2019年 01期
【分类号】R749.4攻读期成果
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