2021/08/13
论文
论文标题：A metabolic function of the hippocampal sharp wave-ripple
作者：Tingley, David, McClain, Kathryn, Kaya, Ekin, Carpenter, Jordan, Buzsáki, György
期刊：Nature
发表时间：2021/08/11
数字识别码：10.1038/s41586-021-03811-w
摘要：The hippocampus has previously been implicated in both cognitive and endocrine functions1,2,3,4,5,6,7,8,9,10,11,12,13,14,15. We simultaneously measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats to identify an activity pattern that may link these disparate functions of the hippocampus. Here we report that clusters of sharp wave-ripples recorded from the hippocampus reliably predicted a decrease in peripheral glucose concentrations within about 10 min. This correlation was not dependent on circadian, ultradian or meal-triggered fluctuations, could be mimicked with optogenetically induced ripples in the hippocampus (but not in the parietal cortex) and was attenuated to chance levels by pharmacogenetically suppressing activity of the lateral septum, which is the major conduit between the hippocampus and the hypothalamus. Our findings demonstrate that a function of the sharp wave-ripple is to modulate peripheral glucose homeostasis, and offer a mechanism for the link between sleep disruption and blood glucose dysregulation in type 2 diabetes16,17,18.
2021年8月11日，来自美国纽约大学的György Buzsáki团队在Nature杂志在线发表了题为A metabolic function of the hippocampal sharp wave-ripple的研究论文揭示了看似无关又相互独立的认知能力和机体代谢功能之间，可以通过海马尖波涟漪（SPW-Rs）连接起来。
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