论文
论文标题：Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
作者：David R. Martinez , Alexandra Schäfer , Sarah R. Leist , Gabriela De la Cruz , Ande West , Elena N. Atochina-Vasserman , Lisa C. Lindesmith , Norbert Pardi , Robert Parks , Maggie Barr , Dapeng Li , Boyd Yount , Kevin O. Saunders , Drew Weissman , Barton F. Haynes , Stephanie A. Montgomery , Ralph S. Baric
期刊：Science
发表时间：2021/06/22
数字识别码：10.1126/science.abi4506
摘要：The emergence of SARS-CoV in 2003 and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against the broader Sarbecovirus subgenus. Using chimeric spike designs, we demonstrate protection against challenge from SARS-CoV, SARS-CoV-2, SARS-CoV-2 B.1.351, bat CoV (Bt-CoV) RsSHC014, and a heterologous Bt-CoV WIV-1 in vulnerable aged mice. Chimeric spike mRNAs induced high levels of broadly protective neutralizing antibodies against high-risk Sarbecoviruses. In contrast, SARS-CoV-2 mRNA vaccination not only showed a marked reduction in neutralizing titers against heterologous Sarbecoviruses, but SARS-CoV and WIV-1 challenge in mice resulted in breakthrough infections. Chimeric spike mRNA vaccines efficiently neutralized D614G, mink cluster five, and the UK B.1.1.7., and South African B.1.351 variants of concern. Thus, multiplexed-chimeric spikes can prevent SARS-like zoonotic coronavirus infections with pandemic potential.
参考资料：
[1] David Martinez et al., (2021), Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice, Science, DOI: 10.1126/science.abi4506
[2] New universal vaccine targets coronaviruses to prevent future pandemics, Retrieved June 22, 2021, from https://www.eurekalert.org/pub_r ... /uonc-nuv062121.php
