论文
论文标题：Estimating infectiousness throughout SARS-CoV-2 infection course
作者：Terry C. Jones , Guido Biele , Barbara Mühlemann , Talitha Veith , Julia Schneider , Jörn Beheim-Schwarzbach , Tobias Bleicker , Julia Tesch , Marie Luisa Schmidt , Leif Erik Sander , Florian Kurth , Peter Menzel , Rolf Schwarzer , Marta Zuchowski , Jörg Hofmann , Andi Krumbholz , Angela Stein , Anke Edelmann , Victor Max Corman , Christian Drosten
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期刊：Science
发表时间：2021/05/25
数字识别码：10.1126/science.abi5273
摘要：Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 German SARS-CoV-2 cases, including 6110 from test centres attended by pre-symptomatic, asymptomatic, and mildly-symptomatic (PAMS) subjects, 9519 who were hospitalised, and 1533 B.1.1.7 lineage infections. The youngest had mean log10 viral load 0.5 (or less) lower than older subjects and an estimated ~78% of the peak cell culture replication probability, due in part to smaller swab sizes and unlikely to be clinically relevant. Viral loads above 109 copies per swab were found in 8% of subjects, one-third of whom were PAMS, with mean age 37.6. We estimate 4.3 days from onset of shedding to peak viral load (8.1) and cell culture isolation probability (0.75). B.1.1.7 subjects had mean log10 viral load 1.05 higher than non-B.1.1.7, with estimated cell culture replication probability 2.6 times higher.
参考资料：
[1] Terry C. Jones, et al., (2021), Estimating infectiousness throughout SARS-CoV-2 infection course, Science, DOI: 10.1126/science.abi5273
[2] SARS-CoV-2: Estimating infectiousness, Retrieved May 25, 2021, from https://www.eurekalert.org/pub_r ... /c-ub-sei052521.php
