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[本文编辑] 姬静芳
Effects of sympathetic nerves in the pathogenesis of essential hypertension
FANG Sheng-lin
The Disease Control and Prevention Center of Hailar Railway, Hulunbuir 021000, Inner Mongolia, China
[Abstract]The pathogenesis of essential hypertension is complicated, involving both genetic susceptibility and environmental stimuli. A large number of studies demonstrate that most essential hypertension results from dysfunction of pressure regulation, mainly due to too strong elevated effects, which are stronger than the body's ability to balance blood pressure. The tension of sympathetic nerves, activation of the renin-angiotensin-aldosterone system, and renal water-sodium retention are the main ways of increasing the pressure, and sympathetic nerve activity is the link between the three. It is generally believed that abnormal sympathetic nerve activation and increased release of aldosterone are major initiating factors of essential hypertension. The abnormal activation of sympathetic nerves may be partly due to structural changes of sympathetic nerves coupled with functional enhancement, and the decreased innate ability of mutual inhibition between sympathetic nerves.
