近日，顶尖学术期刊Cell发表了一篇题为“Hybrid Gene Origination Creates Human-Virus Chimeric Protein during Infection”的研究报道。显示了病毒在感染人体时会将自己的基因与人类基因进行拼接，并且产生同时携带病毒和人类遗传信息的融合蛋白。
学术经纬
·
2020/06/19
论文
论文标题：Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection
作者：Jessica Sook Yuin Ho, Matthew Angel, Yixuan Ma, Elizabeth Sloan, Guojun Wang, Carles Martinez-Romero, Marta Alenquer, Vladimir Roudko, Liliane Chung, Simin Zheng, Max Chang, Yesai Fstkchyan, Sara Clohisey, Adam M. Dinan, James Gibbs, Robert Gifford, Rong Shen, Quan Gu, Nerea Irigoyen, Laura Campisi, Cheng Huang, Nan Zhao, Joshua D. Jones, Ingeborg van Knippenberg, Zeyu Zhu, Natasha Moshkina, Le´ a Meyer, Justine Noel, Zuleyma Peralta, Veronica Rezelj, Robyn Kaake, Brad Rosenberg, Bo Wang, Jiajie Wei, Slobodan Paessler, Helen M. Wise, Jeffrey Johnson, Alessandro Vannini, Maria Joa˜ o Amorim, J. Kenneth Baillie, Emily R. Miraldi, Christopher Benner, Ian Brierley, Paul Digard, Marta quksza, Andrew E. Firth, Nevan Krogan, Benjamin D. Greenbaum, Megan K. MacLeod, Harm van Bakel, Adolfo Garcı`a-Sastre, Jonathan W. Yewdell, Edward Hutchinson, Ivan Marazzi
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期刊：Cell
发表时间：2020/06/19
数字识别码：10.1016/j.cell.2020.05.035
摘要：RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral polymerases cleave 50 -m7G-capped host transcripts to prime viral mRNA synthesis (‘‘cap-snatching’’). We hypothesized that start codons within cap-snatched host transcripts could generate chimeric human-viral mRNAs with coding potential. We report the existence of this mechanism of gene origination, which we named ‘‘start-snatching.’’ Depending on the reading frame, start-snatching allows the translation of host and viral ‘‘untranslated regions’’ (UTRs) to create N-terminally extended viral proteins or entirely novel polypeptides by genetic overprinting. We show that both types of chimeric proteins are made in IAV-infected cells, generate T cell responses, and contribute to virulence. Our results indicate that during infection with IAV, and likely a multitude of other human, animal and plant viruses, a host-dependent mechanism allows the genesis of hybrid genes.
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所属学科：
生物
病毒学
药明康德内容团队
