那么,是否有一种方法,能够阻止MICA 和 MICB这类蛋白从肿瘤表面脱落,从而让免疫系统能发挥抗癌作用呢?这正是Kai W. Wucherpfennig教授带领的团队在题为“Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity”的Science论文中回答的问题。
Histological analysis (Fontana-Masson staining) of lung tissue demonstrated an apparent reduction in the number and size of metastases in mice that were treated with the MICA antibody (representative of five mice). Credit: Science (2018). DOI: 10.1126/science.aao0505
NK细胞加入抗癌行列
针对这项癌症免疫疗法新进展,来自加州大学旧金山分校的Lewis Lanier博士以及海德堡大学的Adelheid Cerwenka博士在同期的Science杂志上发表了一篇题为《自然杀伤细胞加入抗癌行列》(Natural killers join the fight against cancer)的观点文章。