作者: 邓文龙 时间: 2015-12-24 13:36
Therapeutic targeting of casein kinase 1δ in breast cancer
Laura H. Rosenberg1,2, Marie Lafitte1, Victor Quereda1, Wayne Grant1, Weimin Chen1, Mathieu Bibian3, Yoshihiko Noguchi3, Mohammad Fallahi4, Chunying Yang5,6, Jenny C. Chang7, William R. Roush3, John L. Cleveland5,6 and Derek R. Duckett1,*
New way to target breast cancer Casein kinase 1δ (CK1δ) is a protein that helps regulate a variety of cellular processes and is overexpressed in a large percentage of breast and other cancers. Rosenberg et al. show that CK1δ contributes to the growth of breast tumors by activating the Wnt signaling pathway, which is carcinogenic, and that it can be inhibited by RNA interference or by a small-molecule drug. Treatment with a small-molecule inhibitor of CK1δ, called SR-3029, was effective at reducing the growth of breast cancer in multiple mouse models without any signs of major toxicity, suggesting that this therapeutic approach may be a good candidate for testing in human patients.
