在刚回大阪的头几年,Shinya由于刚起步,只能得到少量的研究资助,他不得不自己一个人养几百只小鼠,日子过得非常艰苦。同时大阪市立大学医学院的基础研究很薄弱,周围的人不理解Shinya研究Nat1在胚胎干细胞中的功能有什么意义,总是劝说Shinya做一些更靠近医药临床方面的研究。而Nat1的研究论文提交给杂志后一直被据稿。种种压力与不得志,Shinya因之得了一种病叫PAD(Post America Depression,离开美国后的抑郁症;自创的玩笑话),几乎要放弃科研回国做骨科医生。
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